Cloniprazepam Explained

Cloniprazepam is a benzodiazepine derivative and a prodrug of clonazepam, 7-aminoclonazepam, and other metabolites.^{[1] [2]}

Some of the minor metabolites include 3-hydroxyclonazepam and 6-hydroxyclonazepam, 3-hydroxycloniprazepam and ketocloniprazepam with ketone group formed where 3-hydroxy group was.^[1]

It is a designer drug and an NPS (short for "new psychoactive substance").^[1] At the end of 2017, cloniprazepam was an uncontrolled substance in most of the countries.

See also

• Flutoprazepam
• Ro05-4082
• List of designer drugs
• List of benzodiazepines
• List of benzodiazepine designer drugs

External links

• https://www.unodc.org/LSS/Substance/Details/d115de07-ab8f-4454-a8f7-3ea15f4a0748
• https://web.archive.org/web/20160623204002/http://nsddb.eu/substance/590/

Notes and References

1. Moosmann B, Bisel P, Franz F, Huppertz LM, Auwärter V . Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines - an update comprising adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam and nitrazolam . Journal of Mass Spectrometry . 51 . 11 . 1080–1089 . November 2016 . 27535017 . 10.1002/jms.3840 . 2016JMSp...51.1080M .
2. Mortelé O, Vervliet P, Gys C, Degreef M, Cuykx M, Maudens K, Covaci A, van Nuijs AL, Lai FY . 6 . In vitro Phase I and Phase II metabolism of the new designer benzodiazepine cloniprazepam using liquid chromatography coupled to quadrupole time-of-flight mass spectrometry . Journal of Pharmaceutical and Biomedical Analysis . 153 . 158–167 . May 2018 . 29494888 . 10.1016/j.jpba.2018.02.032 . 3946404 . 10067/1496330151162165141 . free .