Clogestone acetate explained

Clogestone acetate (developmental code name AY-11440), also known as chlormadinol acetate or as 3β,17α-diacetoxy-6-chloropregna-4,6-diene-20-one,^[1] is a steroidal progestin which was investigated as a progestin-only contraceptive and postcoital contraceptive but was never marketed.^{[2] [3] [4] [5]} It is the diacetate ester of clogestone, which, similarly was never marketed. Clogestone acetate produces chlormadinone acetate as an active metabolite.^[6]

See also

• List of progestogens
• List of progestogen esters

Notes and References

1. Book: Litwack G . Biochemical Actions of Hormones. 2 December 2012. Elsevier. 978-0-323-15189-4. 323–.
2. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 297–.
3. Book: Hawkins DR, Elder MG . Human Fertility Control: Theory and Practice. 22 October 2013. Elsevier Science. 978-1-4831-6361-1. 3–.
4. Book: Harper MJ . Contraception — retrospect and prospect . Progress in Drug Research, vol. 21. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des rechersches pharmaceutiques. 21 . 293–407 . 8 March 2013 . 339271 . https://books.google.com/books?id=VFb2BwAAQBAJ&pg=PA321 . Birkhäuser . 10.1007/978-3-0348-7098-6_4 . 978-3-0348-7098-6 .
5. Hinselmann M, Jürgensen O, Hasselblatt I, Otten U, Prinz W, Taubert HD . [Clogestone acetate, a new orally effective progestagen] . de . Archiv Fur Gynakologie . 209 . 2 . 136–148 . August 1970 . 5537778 . 10.1007/BF00668180 .
6. Stern MD, Givner ML . Measurement of serum clogestone acetate (AY-11,440) by a radioreceptor assay: a practical approach to the quantitative determination of synthetic progestins . The Journal of Clinical Endocrinology and Metabolism . 40 . 4 . 728–731 . April 1975 . 1127082 . 10.1210/jcem-40-4-728 .