Clodagh O'Shea explained

Clodagh O'Shea
Birth Place:	Cork
Education:	University College Cork (BS)Imperial College London (PhD)
Occupation:	Professor of molecular and cell biology
Employer:	Salk Institute for Biological Sciences
Known For:	Virally targeting cancer cells
Website:	https://www.salk.edu/scientist/clodagh-oshea/

Clodagh C. O'Shea is a professor of molecular and cell biology and current Wicklow Chair at the Salk Institute for Biological Sciences and a scholar at the Howard Hughes Medical Institute.^[1] She is also an adjunct professor at UCSD^[2] and the Scientific Founder of IconOVir Bio.^[3]

Education

Born and raised in Cork, Ireland, O'Shea has a BS in biochemistry and microbiology from University College Cork, Ireland. She obtained a PhD from Imperial College London, revealing key signals that regulate the development of our immune systems. After her graduate studies, she was selected for a Raleigh International expedition to Namibia where she worked on environmental, conservation and development projects.^[4] She was a Postdoctoral Fellow at the UCSF Comprehensive Cancer Center, San Francisco, United States.

Career and research

O’Shea joined the faculty at the Salk Institute in 2007. She was promoted to associate professor in 2013, and Full Professor in 2018. O’Shea's group designs synthetic viruses. Her team also developed ChromEMT, which enables the 3D folding of genomic DNA to be visualized in the cell nucleus, revealing the chromatin structures that determine gene activation and cell fate.

O’Shea is the Scientific Founder of IconOVir Bio and Chair of IconOVir's Scientific Advisory Board. The clinical-stage biotechnology company hopes to pioneer the next generation of oncolytic virus therapy to improve the treatment of patients with cancer.^{[5] [6]}

Selected publications

• O'Shea . Clodagh C. . Choi . Serah . McCormick . Frank . Stokoe . David . Adenovirus Overrides Cellular Checkpoints for Protein Translation . Cell Cycle . 2 May 2005 . 4 . 7 . 883–888 . 10.4161/cc.4.7.1791. 15970698 . free .
• Ringshausen . Ingo . O'Shea . Clodagh C. . Finch . Andrew J. . Swigart . Lamorna Brown . Evan . Gerard I. . December 2006 . Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo . Cancer Cell . 10 . 6 . 501–514 . 10.1016/j.ccr.2006.10.010. 17157790 . free .
• Heimbucher . Thomas . Liu . Zheng . Bossard . Carine . McCloskey . Richard . Carrano . Andrea C. . Riedel . Christian G. . Tanasa . Bogdan . Klammt . Christian . Fonslow . Bryan R. . Riera . Celine E. . Lillemeier . Bjorn F. . July 2015 . The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity . Cell Metabolism . 22 . 1 . 151–163 . 10.1016/j.cmet.2015.06.002 . 4502596 . 26154057.
• Shah . Govind A. . O'Shea . Clodagh C. . August 2015 . Viral and Cellular Genomes Activate Distinct DNA Damage Responses . Cell . 162 . 5 . 987–1002 . 10.1016/j.cell.2015.07.058 . 4681434 . 26317467.
• Higginbotham . Jennifer M. . O'Shea . Clodagh C. . 15 October 2015 . Imperiale . M. J. . Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains . Journal of Virology . 89 . 20 . 10260–10272 . 10.1128/JVI.01091-15 . 0022-538X . 4580165 . 26223632.
• Ou . Horng D. . Deerinck . Thomas J. . Bushong . Eric . Ellisman . Mark H. . O'Shea . Clodagh C. . November 2015 . Visualizing viral protein structures in cells using genetic probes for correlated light and electron microscopy . Methods . 90 . 39–48 . 10.1016/j.ymeth.2015.06.002 . 4655137 . 26066760.
• Tufail . Yusuf . Cook . Daniela . Fourgeaud . Lawrence . Powers . Colin J. . Merten . Katharina . Clark . Charles L. . Hoffman . Elizabeth . Ngo . Alexander . Sekiguchi . Kohei J. . O'Shea . Clodagh C. . Lemke . Greg . February 2017 . Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia . Neuron . 93 . 3 . 574–586.e8 . 10.1016/j.neuron.2016.12.021 . 5600182 . 28111081.
• Ou . Horng D. . Phan . Sébastien . Deerinck . Thomas J. . Thor . Andrea . Ellisman . Mark H. . O'Shea . Clodagh C. . 28 July 2017 . ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells . Science . 357 . 6349 . eaag0025 . 10.1126/science.aag0025 . 0036-8075 . 5646685 . 28751582.
• Dekker . Job. Job Dekker. Belmont . Andrew S. . Guttman . Mitchell . Leshyk . Victor O. . Lis . John T.. John T. Lis . Lomvardas . Stavros . Mirny . Leonid A. . O'Shea . Clodagh C. . Park . Peter J. . Ren . Bing . Politz . Joan C. Ritland . Shendure . Jay . Zhong . Sheng . The 4D nucleome project . Nature . 14 September 2017 . 549 . 7671 . 219–226 . 10.1038/nature23884. 28905911 . 5617335 . 2017Natur.549..219D .

Awards

• 2007 Emerald Foundation Scholar^[7]
• 2008 ACGT Young Investigator Award for Cancer Gene Therapy^[8]
• 2008 Arnold and Mabel Beckman Young Investigators Award^[9]
• 2009 Sontag Distinguished Scientist Award^[10]
• 2011 Science/NSF International Science & Visualization Challenge, People's Choice^[11]
• 2016 Howard Hughes Medical Institute Faculty Scholar^[12]
• 2018 Paul G. Allen Frontiers Group's Allen Distinguished Investigator^{[13] [14]}

Further reading

• Guest Editor . Oncogene . 21 November 2005 . 24 . 52 . 7635 . 10.1038/sj.onc.1209036. free .
• News: Robbins . Gary . 28 June 2010 . Meet the Scientist . The San Diego Union-Tribune . E-2.
• News: Fikes . Bradley J. . 27 July 2017 . Salk Institute, UCSD scientists decode DNA's 3D shape . The San Diego Union-Tribune.
• Pickett . Mallory . 21 April 2019 . I Want What My Male Colleague Has, and That Will Cost a Few Million Dollars . The New York Times Magazine . 50 . "Clodagh O'Shea was promoted to full professor in February 2018, the first woman to achieve that rank [at the Salk Institute] since [Beverly M.] Emerson in 1999.".
• Perkel . Jeffrey M. . The new techniques revealing the varied shapes of chromatin . Nature . 6 May 2019 . 569 . 7755 . 293–294 . 10.1038/d41586-019-01426-w. 31061461 . free . 2019Natur.569..293P .

Notes and References

1. Web site: Clodagh O'Shea . Salk Institute . 14 March 2020.
2. Web site: UCSD directory .
3. Web site: Iconovir . 4 January 2021 .
4. Web site: Society for Biological Engineering . 27 December 2017 .
5. 11 July 2023 . businesswire .
6. Web site: 5 January 2021 . Bloomberg . .
7. Web site: Clodagh O'Shea. Salk Institute for Biological Studies. en. 2020-03-25.
8. Web site: 24 March 2008 . Salk News .
9. Web site: Awarded Scientists. Arnold and Mabel Beckman Foundation. 2020-02-26.
10. Web site: 22 October 2009 . Salk News .
11. Web site: 2 February 2012 . National Science Foundation .
12. Web site: 22 December 2016 . Salk News .
13. Web site: Assembling DNA into cromatin. Salk News.
14. Web site: 30 October 2018 . Bioengineer.org .