Clifford Tabin Explained

Cliff Tabin
Birth Name:Clifford James Tabin
Birth Date:19 January 1954
Birth Place:Glencoe, Illinois
Thesis Title:Activation of the c-Ha-ras Oncogene
Thesis Url:http://www.worldcat.org/oclc/13089293
Thesis Year:1984
Doctoral Advisor:Robert Weinberg
Known For:Sonic hedgehog[1]
Parents:Julius Tabin

Clifford James Tabin (born 1954)[2] is chairman of the Department of Genetics at Harvard Medical School.[3] [4]

Education

Tabin was educated at the University of Chicago where he was awarded a BS in physics in 1976.[3] He went on to graduate school at Massachusetts Institute of Technology and was awarded a PhD in 1984 for work on the regulation of gene expression in the Ras subfamily of oncogenes supervised by Robert Weinberg based in the MIT Department of Biology.[5] In Weinberg's lab, Tabin constructed murine leukemia virus,[6] the first recombinant retrovirus that could be used as a eukaryotic vector.[4]

Career

Following his PhD, Tabin did postdoctoral research with Douglas A. Melton at Harvard University, then moved to Massachusetts General Hospital where he worked on the molecular biology of limb development. He was appointed to the faculty in the Department of Genetics at Harvard Medical School in 1989, and promoted to full professor in 1997 and chairman of the department in January 2007.[7] [8]

Research

Tabin's research[9] investigates the genetic regulation of vertebrate development,[10] [11] [12] combining classical methods of experimental embryology with modern molecular and genetic techniques for regulating gene expression during embryogenesis.[13] [14] [15]

Previously Tabin has worked on retroviruses, homeobox genes, oncogenes, developmental biology and evolution. Early in his research he investigated limb regeneration in the salamander, and described the expression of retinoic acid receptor and Hox genes in the blastema. Comparative studies by Ann Burke[16] [17] in his lab showed that differences in boundaries of Hox gene expression correlated with differences in skeletal morphology.[18] [19] [20] [21] The Tabin laboratory adjoins the laboratory of Connie Cepko.[22]

Awards and honors

Tabin was elected a Foreign Member of the Royal Society (ForMemRS) in 2014. His nomination reads:

Tabin has also been awarded the Edwin Conklin Medal in 2012, the March of Dimes Prize in Developmental Biology jointly with Philip A. Beachy in 2008 and the NAS Award in Molecular Biology in 1999. He was elected a member of the National Academy of Sciences in 2007and the American Academy of Arts and Sciences in 2000. He was elected a Member of the American Philosophical Society in 2019.

Personal life

Tabin is the son of Julius Tabin,[3] [4] [23] a nuclear physicist who worked with Enrico Fermi on the Manhattan Project in Los Alamos National Laboratory in New Mexico during World War II. He has a brother, Geoff Tabin, and two children. Tabin appears as himself in a BBC Horizon programme titled Hopeful Monsters.

Notes and References

  1. 10.1016/0092-8674(93)90626-2. Sonic hedgehog mediates the polarizing activity of the ZPA. Cell. 75. 7. 1401–16. 1993. Riddle . R. D. . Johnson . R. L. . Laufer . E. . Tabin . C. . 8269518. 4973500.
  2. https://drb.hms.harvard.edu/node/88 Cliff Tabin
  3. Mossman . K. . Profile of Clifford Tabin . 10.1073/pnas.0903946106 . Proceedings of the National Academy of Sciences . 106 . 21 . 8407–8409 . 2009 . 19458049 . 2688980 . 2009PNAS..106.8407M . free .
  4. 19557679. 2009. Tabin. C. Molecular tools, classic questions - an interview with Clifford Tabin. Interviewed by Richardson, Michael K. The International Journal of Developmental Biology. 53. 5–6. 725–31. 10.1387/ijdb.072575mr. free.
  5. PhD . Clifford James. Tabin . Activation of the c-Ha-ras Oncogene . Massachusetts Institute of Technology . 1984 . 13089293.
  6. 6283119. 256749. 1982. Goff. S. P.. Transfection of fibroblasts by cloned Abelson murine leukemia virus DNA and recovery of transmissible virus by recombination with helper virus. Journal of Virology. 41. 1. 271–85. Tabin. C. J.. Clifford Tabin. Wang. J. Y.. Weinberg. R. Robert Weinberg (biologist). Baltimore. D. David Baltimore. 10.1128/JVI.41.1.271-285.1982.
  7. http://molbio.princeton.edu/events/event/147-Tabin Cliff Tabin molbio seminar
  8. 10.1073/pnas.0504834102. The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proceedings of the National Academy of Sciences. 102. 31. 10898–903. 2005. Harfe . B. D.. McManus . M. T.. Mansfield . J. H.. Hornstein . E.. Tabin . C. J. . 16040801 . 1182454. 2005PNAS..10210898H. free.
  9. https://scholar.google.co.uk/scholar?q=clifford+tabin Clifford Tabin publications
  10. 10.1038/297474a0. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature. 297. 5866. 474–8. 1982. Parada . L. F. . Tabin . C. J. . Shih . C. . Weinberg . R. A. . 6283357. 1982Natur.297..474P. 4338225.
  11. 10.1038/384176a0. Biochemical evidence that Patched is the Hedgehog receptor. Nature. 384. 6605. 176–9. 1996. Marigo . V. . Davey . R. A. . Zuo . Y. . Cunningham . J. M. . Tabin . C. J. . 8906794. 1996Natur.384..176M. 4325188.
  12. 10.1016/S0070-2153(03)53002-2. 12509125. 1 Developmental roles and clinical significance of Hedgehog signaling. Current Topics in Developmental Biology. 53. 1–114. 2003. McMahon . A. P. . Ingham . P. W. . Tabin . C. J. . 9780121531539.
  13. 10.1016/0092-8674(91)90612-3. 1677315. Retinoids, homeoboxes, and growth factors: Toward molecular models for limb development. Cell. 66. 2. 199–217. 1991. Tabin . C. J. . 5269260.
  14. 9323126. 1997. Johnson. R. L.. Molecular models for vertebrate limb development. Cell. 90. 6. 979–90. Tabin. C. J.. 10.1016/s0092-8674(00)80364-5. 16213729. free.
  15. 10.1126/science.273.5275.613. Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein. Science. 273. 5275. 613–22. 1996. Vortkamp . A.. Lee . K.. Lanske . B.. Segre . G. V.. Kronenberg . H. M.. Tabin . C. J. . 8662546. 1996Sci...273..613V. 27737023.
  16. 7768176. 1995. Burke. A. C.. Hox genes and the evolution of vertebrate axial morphology. Development. 121. 2. 333–46. Nelson. C. E.. Morgan. B. A.. Tabin. C. 10.1242/dev.121.2.333.
  17. 8812121. 1996. Burke. A. C.. Virally mediated misexpression of Hoxc-6 in the cervical mesoderm results in spinal nerve truncations. Developmental Biology. 178. 1. 192–7. Tabin. C. J.. 10.1006/dbio.1996.0210. free.
  18. 10.1038/nrc1859. Milestone 17: (1979) First human oncogene: An important difference. Patrick Goymer. Nature Reviews Cancer. Nature. April 2006. 6. S18.
  19. 7902151. 1993. Morgan. B. A.. The role of homeobox genes in limb development. Current Opinion in Genetics & Development. 3. 4. 668–74. Tabin. C. J.. 10.1016/0959-437x(93)90105-x.
  20. 10.1016/j.cell.2006.09.018. 17018270. The Key to Left-Right Asymmetry. Cell. 127. 1. 27–32. 2006. Tabin . C. J. . 1775936. free.
  21. 9708733. 10.1016/S0092-8674(00)81474-9. 1998. Logan. M. The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals. Cell. 94. 3. 307–17. Pagán-Westphal. S. M.. Smith. D. M.. Paganessi. L. Tabin. C. J.. 14375165. Clifford Tabin. free.
  22. http://www.biotechniques.com/BiotechniquesJournal/2004/May/Profile-of-Constance-L.-Cepko-Ph.D./biotechniques-116746.html Profile of Constance L. Cepko, Ph.D
  23. http://articles.chicagotribune.com/2012-09-02/news/ct-met-tabin-obit-20120902_1_atom-trinity-test-nuclear-research Julius Tabin Obituary (1919-2012) Physicist helped develop atom bomb

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