Clesrovimab Explained

Drug Name:	Clesrovimab
Synonyms:	MK-1654
Type:	mab
Legal Status:	Investigational
Cas Number:	2429913-18-6
Unii:	VJO29R4CP9

Clesrovimab (MK-1654) is a fully human monoclonal antibody designed to prevent respiratory syncytial virus (RSV) infections. Developed by Merck, it is in a phase III trial as of 2023. It works differently than nirsevimab.^{[1] [2] [3] [4] [5] [6] [7] [8]}

Notes and References

1. Odumade . Oludare A . van Haren . Simon D . Angelidou . Asimenia . Implications of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pandemic on the Epidemiology of Pediatric Respiratory Syncytial Virus Infection . Clinical Infectious Diseases . 15 August 2022 . 75 . Supplement_1 . S130–S135 . 10.1093/cid/ciac373. 35579506 . 9129219 .
2. Dolgin . Elie . Antibody therapies set to transform respiratory syncytial virus prevention for babies . Nature . 27 September 2023 . 621 . 7980 . S55–S57 . 10.1038/d41586-023-02957-z . 37758887 . 262894944 . en. free .
3. Verwey . Charl . Madhi . Shabir A. . Review and Update of Active and Passive Immunization Against Respiratory Syncytial Virus . BioDrugs . May 2023 . 37 . 3 . 295–309 . 10.1007/s40259-023-00596-4. 37097594 . 10127166 .
4. Cunningham . Steve . Zar . Heather J. . New Interventions to Prevent Respiratory Syncytial Virus Disease in Infants—Time for Equitable Global Access . American Journal of Respiratory and Critical Care Medicine . 15 June 2023 . 207 . 12 . 1556–1557 . 10.1164/rccm.202303-0568VP. 37104655 . 10273123 .
5. Qiu . Xirui . Xu . Siyan . Lu . Yang . Luo . Zichen . Yan . Yangtian . Wang . Chuyue . Ji . Jianjian . Development of mRNA vaccines against respiratory syncytial virus (RSV) . Cytokine & Growth Factor Reviews . December 2022 . 68 . 37–53 . 10.1016/j.cytogfr.2022.10.001. 36280532 . 252877115 .
6. Phuah . Jia Yao . Maas . Brian M. . Tang . Aimin . Zhang . Ying . Caro . Luzelena . Railkar . Radha A. . Swanson . Michael D. . Cao . Yu . Li . Hankun . Roadcap . Brad . Catchpole . Andrew P. . Aliprantis . Antonios O. . Vora . Kalpit A. . Quantification of clesrovimab, an investigational, half-life extended, anti-respiratory syncytial virus protein F human monoclonal antibody in the nasal epithelial lining fluid of healthy adults . Biomedicine & Pharmacotherapy . December 2023 . 169 . 115851 . 10.1016/j.biopha.2023.115851. 37976891 . 265251138 . free .
7. Liszewski . Kathy . Multiple Vaccine Technologies Converge on Respiratory Syncytial Virus: Advances include a bivalent subunit vaccine, a liposome-based adjuvant, an mRNA vaccine, and a passive vaccination approach . Genetic Engineering & Biotechnology News . 1 May 2023 . 43 . 5 . 16–18, 20 . 10.1089/gen.43.05.05. 258583326 .
8. Messina . Alessandro . Germano . Chiara . Avellis . Vincenzo . Tavella . Elena . Dodaro . Valentina . Massaro . Alessio . Vitale . Raffaele . Masturzo . Bianca . Manzoni . Paolo . New strategies for the prevention of respiratory syncytial virus (RSV) . Early Human Development . November 2022 . 174 . 105666 . 10.1016/j.earlhumdev.2022.105666. 36174288 .