Claybaugh Creek is a stream in the Saint Francois Mountains of Iron County in the U.S. state of Missouri.
The headwaters arise high on the south slope of Taum Sauk Mountain about 2000 feet south of the lookout at an elevation of about 1620 feet[1] at 37.5644°N -90.7225°W. The stream flows south and east to its confluence with Minor Creek is at the head of Royal Gorge adjacent to Missouri Route 21[1] at 37.5431°N -90.6822°W and at an elevation of 1063 feet.
Claybaugh Creek has the name of an early charcoal producer.[2]