Clavaric acid explained

Clavaric acid is a lanostane type steroid produced by the mushroom Hypholoma lateritium. Clavaric acid was discovered by Merck Research Laboratories in a random screening of natural extracts. Clavaric acid is a reversible farnesyltransferase inhibitor with an IC₅₀ of 1.3 μM.^{[1] [2]}

Notes and References

1. Lingham RB, Silverman KC, Jayasuriya H, Kim BM, Amo SE, Wilson FR . Clavaric acid and steroidal analogues as Ras- and FPP-directed inhibitors of human farnesyl-protein transferase. . J Med Chem . 1998 . 41 . 23 . 4492–501 . 9804689 . 10.1021/jm980356+. etal.
2. Godio RP, Fouces R, Martín JF . A squalene epoxidase is involved in biosynthesis of both the antitumor compound clavaric acid and sterols in the basidiomycete H. sublateritium . Chem Biol . 2007 . 14 . 12 . 1334–46 . 18096502 . 10.1016/j.chembiol.2007.10.018 . free .