| Consort: | yes |
| Succession: | Archduchess consort of Further Austria |
| Reign: | 19 April 1626 –13 September 1632 |
| Succession2: | Duchess consort of Urbino |
| Reign2: | 3 November 1621 – 28 June 1623 |
| Spouse: | |
| Issue: | |
| House: | Medici |
| Father: | Ferdinando I de' Medici |
| Mother: | Christina of Lorraine |
| Birth Date: | 4 June 1604 |
| Birth Place: | Palazzo Pitti, Florence, Grand Duchy of Tuscany |
| Death Place: | Hofburg, Innsbruck, County of Tyrol, Holy Roman Empire |
Claudia de' Medici (4 June 1604 – 25 December 1648) was Regent of the Austrian County of Tyrol during the minority of her son from 1632 until 1646.
Born in Florence into the House of Medici, Claudia was the youngest daughter of Ferdinando I de' Medici, Grand Duke of Tuscany and his wife, Christina of Lorraine. She was named after her grandmother Claude of Valois, herself daughter of Catherine de Medici, Queen of France, granddaughter of Claude, Duchess of Brittany, consort to King Francis I of France.
In 1620, she married Federico Ubaldo della Rovere, the only son of Francesco Maria II della Rovere, Duke of Urbino. Their only child, Vittoria, went on to marry the Grand Duke of Tuscany. Federico Ubaldo della Rovere died suddenly on 29 June 1623.
After her husband's premature death, she was married, on 19 April 1626, to Leopold V, Archduke of Austria, and thus became Archduchess consort of Austria.
On the death of her husband in 1632, she assumed a regency in the name of her son Ferdinand Charles who was the ruler of the Princely County of Tyrol. Claudia, along with five directors, held the post until 1646. She died at Innsbruck in 1648.
She had one child by Federico Ubaldo della Rovere:
She had five children by Archduke Leopold V of Austria: