| Claude Spanghero | |
| Birth Date: | 5 June 1948 |
| Birth Place: | Payra-sur-l'Hers, France |
| Weight: | 104 kg |
| Ru Position: | Lock, number eight |
| Ru Nationalteam: | France |
| Ru Nationalyears: | 1971–1975 |
| Ru Nationalcaps: | 22 |
| Ru Clubyears: | ?–1980 1980-? |
| Ru Proclubs: | Narbonne Sporting club appaméen |
| Relatives: | Walter Spanghero Nicolas Spanghero |
Claude Spanghero (born 5 June 1948) is a former French rugby union footballer. He was a part of the French side which won the Five Nations in 1973. He played for France over 22 times and 7 with his Brother Walter Spanghero. He played at number 8 and Lock. He famously had a very stormy relationship with his brother, Walter, who was also an international rugby player for France.