| Claude-François Duprès | |
| Birth Date: | October 3, 1755 |
| Birth Place: | Fort-Louis, Alsace, France |
| Death Place: | Bailén, Spain |
| Allegiance: | Kingdom of France, First French Republic, First French Empire |
| Rank: | Général de brigade |
| Serviceyears: | 1776-1808 |
| Serviceyears Label: | Active |
| Branch: | Cavalry |
| Battles: | |
| Awards: | Commander of the Légion d'honneur Baron d'Empire |
Claude François Dupré or Claude François Duprès (pronounced as /fr/; 3 October 1755 – 21 July 1808) was a French general.
Born in Fort-Louis, Bas-Rhin, he first joined up in 1776 and served in the armies of the French Revolution and First French Empire. He was killed at Battle of Bailén in Bailén, Andalucia.