Class II PI 3-kinases explained

Class II PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation.

Class II PI 3-kinases were the most recently identified class of PI 3-kinases.

There are three class II PI 3-kinase isoforms expressed in mammalian cells;

• PI3K-C2α encoded by the PIK3C2A gene
• PI3K-C2β encoded by the PIK3C2B gene
• PI3K-C2γ encoded by the PIK3C2G gene

See also

• Phosphoinositide 3-kinase

References

• Stein RC . Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment . Endocrine-Related Cancer . 8 . 3 . 237–248 . September 2001 . 11566615 . 10.1677/erc.0.0080237 .
• Foster FM, Traer CJ, Abraham SM, Fry MJ . The phosphoinositide (PI) 3-kinase family . Journal of Cell Science . 116 . Pt 15 . 3037–3040 . August 2003 . 12829733 . 10.1242/jcs.00609 .
• Vanhaesebroeck B, Waterfield MD . Signaling by distinct classes of phosphoinositide 3-kinases . Experimental Cell Research . 253 . 1 . 239–254 . November 1999 . 10579926 . 10.1006/excr.1999.4701 .