| Clarence Cannon National Wildlife Refuge | |
| Iucn Category: | IV |
| Map: | USA#Missouri |
| Relief: | 1 |
| Map Width: | 300 |
| Location: | Pike County, Missouri, United States |
| Nearest City: | Annada, Missouri |
| Coordinates: | 39.267°N -90.784°W |
| Area: | 3750acres |
| Established: | 1964 |
| Governing Body: | U.S. Fish and Wildlife Service |
| Website: | Clarence Cannon National Wildlife Refuge |
The 3750acres Clarence Cannon National Wildlife Refuge is located in the floodplain of the Mississippi River, adjacent to Pool No. 25 in Pike County, Missouri. The refuge's diversity of habitats supports waterfowl, wading birds, shorebirds, and songbirds. Although it is protected by a levee, the refuge provides flood storage in periods of high water.
Clarence Cannon Refuge is managed by Great River National Wildlife Refuge, which is part of the Mark Twain National Wildlife Refuge Complex.