Claire E. Eyers Explained

Claire Eyers (née Haydon) is a British biological mass spectrometrist who is professor of biological mass spectrometry at the University of Liverpool, where she heads up the Centre for Proteome Research.[1] Her research publications list her either as Claire E Haydon (her maiden name) or Claire E Eyers (from 2005).

Early life and education

Eyers was born in London and educated at Putney High School. She was awarded a BSc Honours in Biochemistry with Industrial experience Rhône-Poulenc from the University of Bristol in 1998 prior to undertaking postgraduate studies in the MRC PPU[2] at the University of Dundee where she was awarded a PhD in 2002 for her work on stress-activated protein kinases with Sir Philip Cohen. Her interests in protein phosphorylation and biological mass spectrometry have subsequently led to a series of professional appointments, including (in 2017) an Invited Member of the Scientific Advisory Group of the Human Proteome Organization (HUPO), the Editorial Board of Scientific Reports (2017–), and as an Executive committee & Trustee of the British Mass Spectrometry Society (2015–), for whom she was also Treasurer between 2016 and 2018.

Career and research

Following her PhD in Dundee, Eyers joined the group of Professor Natalie Ahn in the USA, and was awarded an Outstanding Postdoctoral Fellow Award (Pacific/Mountain Affiliate) of the American Heart Association (2004), held at the University of Colorado Boulder.[3] Subsequently, in 2005, she returned to the UK to take up a position with Professor Simon Gaskell as Deputy Head of the Michael Barber Centre for Mass Spectrometry at the University of Manchester. Her work in Manchester, a national and international centre of excellence for mass spectrometry best known for the development of fast atom bombardment (FAB), involved the development, refinement and application of strategies for protein quantification by mass spectrometry, and gas-phase characterisation of modified peptides and glycans. During her time in Manchester, she also contributed to securing the first bronze (2011) and subsequently silver (2013) Athena SWAN (Scientific Women's Academic Network) award for the School of Chemistry. In 2007, Eyers was awarded a personal Royal Society Dorothy Hodgkin Fellowship to set up her own research proteomics laboratory,[4] and was promoted to Senior Lecturer in 2010. Since 2014, she has been the Professor of Biological Mass Spectrometry in the Faculty of Health and Life Sciences at the University of Liverpool[4] and is currently Director of the Centre for Proteome Research.[5] She is currently Research and Impact Lead for the Institute of Integrative Biology at the University of Liverpool, a founder member of the Workload Model Working Group, which oversaw a charter Gold ranking Athena SWAN award for the IIB in 2017, a first for the University of Liverpool.[6] Eyers sits on the Selection Committee for L'Oréal-UNESCO For Women in Science, Professional Body Memberships and is a member of the Royal Society of Chemistry, the American Society for Mass Spectrometry, the British Society for Proteome Research (a member of the UK Biosciences Federation), the British Mass Spectrometry Society and the UK Biochemical Society.[7] Her expertise in protein phosphorylation and biological mass spectrometry have resulted in a number of professional appointments. She is currently Chair of BBSRC Committee D.[8] Alongside Professors Sabine Flitsch and Perdita Barran, Eyers is also Co-founder and Scientific Director of Bio-Shape Ltd, a company specialising in the analysis of proteins, carbohydrates and their conjugates using mass spectrometry-based methods.

Eyers' work in biological mass spectrometry focuses on the global and targeted analysis of post-translational modification on proteins. She has published over 70 research articles, has edited two books ('Quantitative Proteomics' published by RSC Press[9] and 'Histidine Phosphorylation: Methods and Protocols published by Springer Press [10]) and she currently holds two patents.[11] Her most cited publications focus on biochemical, structural, cellular and gas-phase studies of protein phosphorylation,[12] protein kinase complexes[13] [14] [15] and glycan conformation,[16] [17] [18] and several highly-accessed reviews on the subject of ion mobility mass spectrometry for biological molecules.[19] [20] [21] [22] [23] She is highly cited for her analysis of protein phosphorylation by mass spectrometry,[24] [25] and in 2019 work in her lab led to the discovery that non-canonical protein phosphorylation on a broad range of amino acids, including Arg, Asp, Cys, Glu, His and Lys is widespread in human cells.[26] This work potentially opens up an entirely new field of 'non-canonical' protein phosphorylation analysis in prokaryotic and eukaryotic organisms, where protein phosphorylation represents a reversible switch that transmits intracellular signals in response to extracellular factors.[27]

In 2022, Eyers was appointed to the Liverpool City Region Local Enterprise Partnership (LEP) Health and Life Sciences sub-board which aims to support the growth of the Health and Life Sciences sectors in the local area as well as providing support and access to the extensive knowledge and expertise across the Liverpool City region.[28] [29]

Awards and honours

Eyers received the Outstanding Postdoctoral Fellow Award (Pacific/Mountain Affiliate) of the American Heart Association (2004), when working in the laboratory of Professor Natalie Ahn, at the University of Colorado Boulder. Eyers is the 2020 British Society for Proteome Research Named Lecturer.[30] In her role as the BSPR Lecturer, Eyers will be presenting a series of lectures during 2020 and 2021 focused on phosphoproteomics and post translational modification analysis of proteins.

Notes and References

  1. Web site: Centre for Proteome Research – University of Liverpool . www.liverpool.ac.uk . 16 May 2023.
  2. Web site: MRC PPUU – University of Dundee . www.ppu.mrc.ac.uk . 16 May 2023.
  3. Web site: Claire Eyers promoted to Professor. MRC PPU . 2022-08-08 . MRC Protein Phosphorylation and Ubiquitylation Unit . 25 November 2014 . en.
  4. Web site: Faculty of Health and Life Sciences – University of Liverpool . www.liverpool.ac.uk . 16 May 2023.
  5. Web site: Centre for Proteome Research – University of Liverpool.
  6. Web site: Athena SWAN – Institute of Integrative Biology – University of Liverpool . www.liverpool.ac.uk . 3 September 2019 . 3 September 2019 . https://web.archive.org/web/20190903152358/https://www.liverpool.ac.uk/integrative-biology/work-with-us/athena-swan/ . dead .
  7. Web site: BMSS Committee | BMSS . www.bmss.org.uk . 3 September 2019 . 26 August 2019 . https://web.archive.org/web/20190826200816/https://www.bmss.org.uk/about-us/commitee-members/ . dead .
  8. Web site: BBSRC Panel D; BBSRC . bbsrc.ukri.org . 16 May 2023.
  9. Book: Quantitative Proteomics; RSC Press. New Developments in Mass Spectrometry. 2014. The Royal Society of Chemistry . 10.1039/9781782626985. 978-1-84973-808-8 . Eyers . Gaskell . Claire E. . Simon .
  10. Book: Histidine Phosphorylation. Methods in Molecular Biology. 2020. 2077. Springer. 10.1007/978-1-4939-9884-5. 978-1-4939-9883-8. 207988391 .
  11. Web site: Google Scholar.
  12. Ferries S, Perkins S, Brownridge PJ, Campbell A, Eyers PA, Jones AR, Eyers CE. Evaluation of Parameters for Confident Phosphorylation Site Localization Using an Orbitrap Fusion Tribrid Mass Spectrometer.. Journal of Proteome Research. 16. 9. 3448–3459. 2017. 10.1021/acs.jproteome.7b00337. 28741359. free.
  13. Vonderach M, Byrne DP, Barran PE, Eyers PA, Eyers CE. DNA Binding and Phosphorylation Regulate the Core Structure of the NF-κB p50 Transcription Factor.. Journal of the American Society for Mass Spectrometry. 30. 1. 128–138. 2019. 10.1007/s13361-018-1984-0. 29873020. 6318249. 2019JASMS..30..128V.
  14. Smith FD, Esseltine JL, Nygren PJ, Veesler D, Byrne DP, Vonderach M, Strashnov I, Eyers CE, Eyers PA, Langeberg LK, Scott JD. Local protein kinase A action proceeds through intact holoenzymes.. Science. 356. 6344. 1288–1293. 2017. 10.1126/science.aaj1669. 28642438. 5693252. 2017Sci...356.1288S.
  15. Byrne DP, Vonderach M, Ferries S, Brownridge PJ, Eyers CE, Eyers PA. cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility-mass spectrometry. Biochemical Journal. 473. 19. 3159–75. 2016. 27444646. 5095912. 10.1042/BCJ20160648.
  16. Gray CJ, Migas LG, Barran PE, Pagel K, Seeberger PH, Eyers CE, Boons GJ, Pohl NL, Compagnon I, Widmalm G, Flitsch SL. Advancing Solutions to the Carbohydrate Sequencing Challenge.. Journal of the American Chemical Society. 141. 37. 14463–14479. 2019. 10.1021/jacs.9b06406. 31403778. 9397603 . 1874/389150 . 199548971 .
  17. Both P, Green AP, Gray CJ, Sardzík R, Voglmeir J, Fontana C, Austeri M, Rejzek M, Richardson D, Field RA, Widmalm G, Flitsch SL, Eyers CE. Discrimination of epimeric glycans and glycopeptides using IM-MS and its potential for carbohydrate sequencing.. Nature Chemistry. 6. 1. 65–75. 2014. 24345949. 10.1038/nchem.1817. 2014NatCh...6...65B. 205292342.
  18. Gray CJ, Schindler B, Migas LG, Pičmanová M, Allouche AR, Green AP, Mandal S, Motawia MS, Sánchez-Pérez R, Bjarnholt N, Moller BL, Rijs AM, Barran PE, Compagnon I, Eyers CE, Flitsch SL. Bottom-Up Elucidation of Glycosidic Bond Stereochemistry.. Analytical Chemistry. 89. 8. 4540–4549. 2017. 28350444. 10.1021/acs.analchem.6b04998. 2066/174591. 29244587 . free.
  19. Eyers CE, Vonderach M, Ferries S, Jeacock K, Eyers PA. Understanding protein-drug interactions using ion mobility-mass spectrometry.. Current Opinion in Chemical Biology. 42. 167–176. 2018. 29331721. 10.1016/j.cbpa.2017.12.013. free.
  20. Gray CJ, Thomas B, Upton R, Migas LG, Eyers CE, Barran PE, Flitsch SL. Applications of ion mobility mass spectrometry for high throughput, high resolution analysis.. Biochimica et Biophysica Acta (BBA) - General Subjects. 1860. 8. 1688–1709. 2016. 26854953. 10.1016/j.bbagen.2016.02.003.
  21. Lanucara F, Holman SW, Gray CJ, Eyers CE. The power of ion mobility-mass spectrometry for structural characterization and the study of conformational dynamics.. Nature Chemistry. 6. 4. 281–294. 2014. 24651194. 10.1038/nchem.1889. 2014NatCh...6..281L.
  22. Gonzalez-Sanchez MB, Lanucara F, Hardman GE, Eyers CE. Gas-phase intermolecular phosphate transfer within a phosphohistidine phosphopeptide dimer.. International Journal of Mass Spectrometry. 367. 28–34. 2014. 25844054. 4375673. 10.1016/j.ijms.2014.04.015. 2014IJMSp.367...28G.
  23. Gonzalez-Sanchez MB, Lanucara F, Helm M, Eyers CE. Attempting to rewrite History: challenges with the analysis of histidine-phosphorylated peptides.. Biochemical Society Transactions. 41. 4. 1089–1095. 2013. 23863184. 10.1042/bst20130072.
  24. Haydon CE, Eyers PA, Aveline-Wolf LD, Resing KA, Maller JL, Ahn NG. Identification of novel phosphorylation sites on Xenopus laevis Aurora A and analysis of phosphopeptide enrichment by immobilized metal-affinity chromatography.. Molecular & Cellular Proteomics. 2. 10. 1055–1067. 2003. 10.1074/mcp.M300054-MCP200. 12885952. free.
  25. Haydon CE, Watt PW, Morrice N, Knebel A, Gaestel M, Cohen P. Identification of a phosphorylation site on skeletal muscle myosin light chain kinase that becomes phosphorylated during muscle contraction.. Archives of Biochemistry and Biophysics. 397. 2. 224–231. 2003. 10.1006/abbi.2001.2625. 11795875.
  26. Hardman G, Perkins S, Brownridge PJ, Clarke CJ, Byrne DP, Campbell AE, Kalyuzhnyy A, Myall A, Eyers PA, Jones AR, Eyers CE. Strong anion exchange-mediated phosphoproteomics reveals extensive human non-canonical phosphorylation.. The EMBO Journal. 38. 21. e100847. 2019. 31433507. 10.15252/embj.2018100847. 6826212.
  27. Hunter T. Why nature chose phosphate to modify proteins.. Philosophical Transactions of the Royal Society B: Biological Sciences. 367. 1602. 2513–6. 2012. 10.1098/rstb.2012.0013. 22889903. 3415839.
  28. Web site: Stories - Institute of Systems, Molecular and Integrative Biology - University of Liverpool . 2022-08-08 . www.liverpool.ac.uk.
  29. Web site: Health & Life Sciences . 2022-08-08 . Liverpool Enterprise Partnership . en-US.
  30. Web site: British Society for Proteome Research; BSPR . 16 May 2023 . www.bspr.org.
  31. Web site: Professor Claire Eyers - 2022 Chemistry Biology Interface Division mid-career Award: Jeremy Knowles Award winner . 2022-08-08 . Royal Society of Chemistry . en-GB.

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