Cl-4AS-1 explained

Cl-4AS-1 is a dual anabolic–androgenic steroid (AAS) and 5α-reductase inhibitor.^{[1] [2]} It is a potent and selective full agonist of the androgen receptor (IC₅₀ = 12 nM) and inhibitor of 5α-reductase types I and II (IC₅₀ = 6 and 10 nM, respectively). Structurally, Cl-4AS-1 is a 4-azasteroid.

See also

• TFM-4AS-1

External links

• Cl-4AS-1 - Santa Cruz Biotechnology

Notes and References

1. Tolman RL, Sahoo SP, Bakshi RK, Gratale D, Patel G, Patel S, Toney J, Chang B, Harris GS . 4-Methyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-N-aryl-carboxamides: an approach to combined androgen blockade [5alpha-reductase inhibition with androgen receptor binding in vitro] . J. Steroid Biochem. Mol. Biol. . 60 . 5–6 . 303–9 . 1997 . 9219921 . 10.1016/s0960-0760(96)00199-9. 54405031 .
2. Schmidt A, Harada S, Kimmel DB, Bai C, Chen F, Rutledge SJ, Vogel RL, Scafonas A, Gentile MA, Nantermet PV, McElwee-Witmer S, Pennypacker B, Masarachia P, Sahoo SP, Kim Y, Meissner RS, Hartman GD, Duggan ME, Rodan GA, Towler DA, Ray WJ . Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands . J. Biol. Chem. . 284 . 52 . 36367–76 . 2009 . 19846549 . 2794752 . 10.1074/jbc.M109.049734 . free .