| Official Name: | City Railway Colony |
| Coordinates: | 24.8474°N 67.0123°W |
| Settlement Type: | Neighbourhood |
| Subdivision Type: | Country |
| Subdivision Name: | Pakistan |
| Subdivision Type1: | Province |
| Subdivision Name1: | Sindh |
| Subdivision Type2: | City District |
| Subdivision Name2: | Karachi South |
| Timezone: | PKT |
| Utc Offset: | +5 |
City Railway Colony (Urdu: سٹی ریلوے کالونی) is a neighbourhood in Saddar Town[1] in Karachi, Pakistan, and is part of the administrative district Karachi South.
The colony is comprising the entire area south of the Karachi City Station and the I. I. Chundrigar Road between the Railway Street with the MagnifiScience Centre is in the west and the Jinnah Courts and PIDC Bridge on the east. The KPT container terminal and the Moulvi Tamizuddin Khan Road builds the southern border.
There are several ethnic groups including Muhajirs, Sindhis, Punjabis, Kashmiris, Seraikis, Pakhtuns, Balochis, Memons, Bohras Ismailis.