Citrate (Re)-synthase explained

citrate (Re)-synthase
Ec Number:	2.3.3.3
Cas Number:	9077-70-7
Go Code:	0050450

In enzymology, a citrate (Re)-synthase is an enzyme that catalyzes the chemical reaction

acetyl-CoA + H₂O + oxaloacetate

\rightleftharpoons citrate + CoA

The 3 substrates of this enzyme are acetyl-CoA, H₂O, and oxaloacetate, whereas its two products are citrate and CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]. Other names in common use include (R)-citrate synthase, Re-citrate-synthase, and citrate oxaloacetate-lyase [(pro-3R)-CH2COO→acetyl-CoA].

References

• Dittbrenner S, Chowdhury AA, Gottschalk G . 1969 . The stereospecificity of the (R)-citrates synthase in the presence of p-chloromercuribenzoate . Biochem. Biophys. Res. Commun. . 36 . 802 - 8 . 5808294 . 10.1016/0006-291X(69)90680-9 . 5 .
• Gottschalk G . 1969 . Partial purification and some properties of the (R)-citrate synthase from Clostridium acidi-urici . Eur. J. Biochem. . 7 . 301 - 6 . 4974734 . 10.1111/j.1432-1033.1969.tb19607.x . 2 . free .
• Gottschalk G, Barker HA . 1966 . Synthesis of glutamate and citrate by Clostridium kluyveri. A new type of citrate synthase . Biochemistry . 5 . 1125 - 33 . 5958189 . 10.1021/bi00868a003 . 4 .