Citrate—CoA ligase explained

Citrate—CoA ligase
Ec Number:	6.2.1.18
Cas Number:	856428-87-0
Go Code:	0047779

In enzymology, a citrate—CoA ligase is an enzyme that catalyzes the chemical reaction

ATP + citrate + CoA

\rightleftharpoons ADP + phosphate + (3S)-citryl-CoA

The 3 substrates of this enzyme are ATP, citrate, and CoA, whereas its 3 products are ADP, phosphate, and (3S)-citryl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is citrate:CoA ligase (ADP-forming). Other names in common use include citryl-CoA synthetase, citrate:CoA ligase, and citrate thiokinase. This enzyme participates in citric acid cycle.

References

• Lill U, Schreil A, Eggerer H . 1982 . Isolation of enzymically active fragments formed by limited proteolysis of ATP citrate lyase . Eur. J. Biochem. . 125 . 645 - 50 . 6749502 . 10.1111/j.1432-1033.1982.tb06731.x . 3 . free .
• Aoshima M, Ishii M, Igarashi Y . 2004 . A novel enzyme, citryl-CoA synthetase, catalysing the first step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6 . Mol. Microbiol. . 52 . 751 - 61 . 15101981 . 10.1111/j.1365-2958.2004.04009.x . 3 . free .