Citramalic acid explained

Citramalic acid is the organic compound with the formula HO2CCH2C(CH3)(OH)CO2H. A chiral compound, it is related structurally to malic acid.

Synthesis and reactions

Citramalic acid is the hydrated derivative of mesaconic acid, The hydration is catalyzed by mesaconyl-C4-CoA hydratase:

HO2CCH=C(CH3)CO2H + H2O → HO2CCH2C(CH3)(OH)CO2HThe same conversion can be achieved in vitro.[1]

The enzyme (S)-citramalyl-CoA lyase converts citramalyl-CoA to acetyl-CoA and pyruvate.[2]

References

  1. 10.1016/S0040-4020(01)85678-7. Preparation of Both Enantiomers of Malic and Ctramalic Acid and Other Hydroxysuccinic Acid Derivatives by Stereospecific Hydrations of cis or trans 2-Butene-1,4-dioic Acids with Resting Cells of Clostridium formicoaceticum. 1994. Eck. Richard. Simon. Helmut. Tetrahedron. 50. 48. 13641–13654.
  2. 10.1128/AEM.02473-10. Ecological Aspects of the Distribution of Different Autotrophic CO2 Fixation Pathways. 2011. Berg. Ivan A.. Applied and Environmental Microbiology. 77. 6. 1925–1936. 21216907. 3067309. 2011ApEnM..77.1925B.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Citramalic acid".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.