Cis-muuroladiene synthase explained

cis-Muuroladiene synthase
Ec Number:	4.2.3.67

cis-Muuroladiene synthase (EC 4.2.3.67, MxpSS1) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cis-muuroladiene-forming).^[1] This enzyme catalyses the following chemical reactions

(1) (2E,6E)-farnesyl diphosphate

\rightleftharpoons cis-muurola-3,5-diene + diphosphate

(2) (2E,6E)-farnesyl diphosphate

\rightleftharpoons cis-muurola-4(14),5-diene + diphosphate

The recombinant enzyme from black peppermint produces a mixture of cis-muurola-3,5-diene and cis-muurola-4(14),5-diene.

Notes and References

1. Prosser IM, Adams RJ, Beale MH, Hawkins ND, Phillips AL, Pickett JA, Field LM . Cloning and functional characterisation of a cis-muuroladiene synthase from black peppermint (Mentha x piperita) and direct evidence for a chemotype unable to synthesise farnesene . Phytochemistry . 67 . 15 . 1564–71 . August 2006 . 16083926 . 10.1016/j.phytochem.2005.06.012 .