Cis-abienol synthase explained

cis-abienol synthase
Ec Number:	4.2.3.140

cis-Abienol synthase (EC 4.2.3.140, Z-abienol synthase, CAS, ABS) is an enzyme with systematic name (13E)-8α-hydroxylabd-13-en-15-yl-diphosphate-lyase (cis-abienol forming).^{[1] [2]} This enzyme catalyses the following chemical reaction

(13E)-8α-hydroxylabd-13-en-15-yl diphosphate

\rightleftharpoons cis-abienol + diphosphate

This enzyme is isolated from the plants Abies balsamea (balsam fir) and Nicotiana tabacum (tobacco).

Notes and References

1. Zerbe P, Chiang A, Yuen M, Hamberger B, Hamberger B, Draper JA, Britton R, Bohlmann J . Bifunctional cis-abienol synthase from Abies balsamea discovered by transcriptome sequencing and its implications for diterpenoid fragrance production . The Journal of Biological Chemistry . 287 . 15 . 12121–31 . April 2012 . 22337889 . 3320957 . 10.1074/jbc.m111.317669 . free .
2. Sallaud C, Giacalone C, Töpfer R, Goepfert S, Bakaher N, Rösti S, Tissier A . Characterization of two genes for the biosynthesis of the labdane diterpene Z-abienol in tobacco (Nicotiana tabacum) glandular trichomes . The Plant Journal . 72 . 1 . 1–17 . October 2012 . 22672125 . 10.1111/j.1365-313x.2012.05068.x . free .