Cis-2-enoyl-CoA reductase (NADPH) explained

cis-2-enoyl-CoA reductase (NADPH)
Ec Number:	1.3.1.37
Cas Number:	72841-00-0
Go Code:	0047774

In enzymology, a cis-2-enoyl-CoA reductase (NADPH) is an enzyme that catalyzes the chemical reaction

acyl-CoA + NADP⁺

\rightleftharpoons cis-2,3-dehydroacyl-CoA + NADPH + H⁺

Thus, the two substrates of this enzyme are acyl-CoA and NADP⁺, whereas its 3 products are cis-2,3-dehydroacyl-CoA, NADPH, and H⁺.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is acyl-CoA:NADP+ cis-2-oxidoreductase. Other names in common use include NADPH-dependent cis-enoyl-CoA reductase, reductase, cis-2-enoyl coenzyme A, cis-2-enoyl-coenzyme A reductase, and cis-2-enoyl-CoA reductase (NADPH).

Further reading

• Mizugaki M, Nishimaki T, Shiraishi T, Kawaguchi A, Okuda S, Yamanaka H . Studies on the metabolism of unsaturated fatty acids. IX. Stereochemical studies of the reaction catalyzed by trans-2-enoyl-coenzyme A reductase of Escherichia coli . Journal of Biochemistry . 92 . 5 . 1649–54 . November 1982 . 6759504 .