| Type: | commune |
| County: | Mehedinți |
| Șișești | |
| Leader Name: | Marian Ion Răducan |
| Leader Party: | Independent |
| Leader Term: | 2020 - 2024 |
| Coordinates: | 44.7833°N 72°W |
| Elevation: | 213 |
| Area Total: | 75.20 |
| Population Total: | auto |
| Postal Code: | 227455 |
Șișești is a commune located in Mehedinți County, Oltenia, Romania. It is composed of six villages: Cărămidaru, Ciovârnășani, Cocorova, Crăguești, Noapteșa, and Șișești.