Cingestol Explained

Cingestol (INN, USAN) (former tentative brand name Lutisan),^[1] also known as 17α-ethynylestr-5-en-17β-ol,^[2] is a steroidal progestin of the 19-nortestosterone group^{[3] [4]} that was never marketed.^[5] It was synthesized in 1969 and was developed in the 1970s by Organon as a low-dose, progestogen-only contraceptive,^{[6] [7] [8] [9]} but in 1984, was still described as "under investigation".^[10] The drug is an isomer of lynestrenol with the double bond between C5 and C6.

See also

• Allylestrenol

Notes and References

1. Book: Registry of Toxic Effects of Chemical Substances. 1987. National Institute for Occupational Safety and Health. 2995.
2. Book: Brotherton J . Sex hormone pharmacology. 1976. Academic Press. 978-0-12-137250-7. 12.
3. Book: Korolkovas A . Essentials of Medicinal Chemistry. 16 August 1988. Wiley. 978-0-471-88356-2.
4. Book: WHO Technical Report Series. 1981. World Health Organization. 75. 9789241206570.
5. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 279–.
6. Book: Tapingkae A . Directory of selected scholars and researchers in Southeast Asia. 1974. Regional Institute of Higher Education and Development. 687.
7. Book: Briggs MH, Briggs M . Biochemical contraception: prospects for human development. 1976. Academic Press. 978-0-12-134640-9. 283.
8. Aref I, Hefnawi F, Kandil O, Aziz MT . Effect of minipills on physiologic responses of human cervical mucus, endometrium, and ovary . Fertility and Sterility . 24 . 8 . 578–583 . August 1973 . 4124151 . 10.1016/s0015-0282(16)39850-8 .
9. Kićović PM, Kovacević S, Djokic LJ, Milojević S, Janoskov J, Behlilović B, Jeremić N . Clinical evaluation of a new low dose progestagen-only contraceptive containing cingestol . International Journal of Fertility . 19 . 3 . 171–175 . 1974 . 4375129 .
10. Book: Cutting WC, Csáky TZ, Barnes BA . Windsor C. Cutting. Cutting's Handbook of Pharmacology: The Actions and Uses of Drugs. 1984. Appleton-Century-Crofts. 978-0-8385-1418-4. 439.