Cinfenine Explained

Class:Antidepressant
Coronary vasodilator
Cas Number:54141-87-6
Pubchem:6443800
Chemspiderid:4947762
Unii:P26FL0O04P
Chembl:2104102
Iupac Name:(E)-N-(2-benzhydryloxyethyl)-N-methyl-3-phenylprop-2-en-1-amine
C:25
H:27
N:1
O:1
Smiles:CN(CCOC(C1=CC=CC=C1)C2=CC=CC=C2)C/C=C/C3=CC=CC=C3
Stdinchi:1S/C25H27NO/c1-26(19-11-14-22-12-5-2-6-13-22)20-21-27-25(23-15-7-3-8-16-23)24-17-9-4-10-18-24/h2-18,25H,19-21H2,1H3/b14-11+
Stdinchikey:QTKQVDXGCWKEHE-SDNWHVSQSA-N

Cinfenine is a drug described as an antidepressant and coronary vasodilator which was never marketed.[1] [2] [3] It was first described in the literature by 1970.[4] The drug is similar in chemical structure to the modafinil derivative and atypical dopamine reuptake inhibitor JJC8-016, as well as to the antihistamine and anticholinergic diphenhydramine and derivatives of diphenhydramine like ebastine.[5]

See also

Notes and References

  1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . Springer US . 2014 . 978-1-4757-2085-3 . 20 October 2024 . 278.
  2. Book: Use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances . 2024 . World Health Organization . 102 . 978-92-4-009938-8 .
  3. Web site: CINFENINE . Inxight Drugs . National Center for Advancing Translational Sciences (NCATS) . 20 October 2024 .
  4. DE . 1936206 . Diphenylmethoxyaethylaminoderivate und Verfahren zu ihrer Herstellung . Koninklijke Pharmaceutische Fabrieken NV . 22 January 1970 .
  5. Web site: Cinfenine . PubChem . U.S. National Library of Medicine . 20 October 2024.