Cinchocaine Explained

Cinchocaine (INN/BAN) or dibucaine (USAN) is an amide local anesthetic. Among the most potent and toxic of the long-acting local anesthetics, current use of cinchocaine is generally restricted to spinal and topical anesthesia.^{[1] [2]} It is sold under the brand names Cincain, Nupercainal, Nupercaine and Sovcaine.

Medical use

Cinchocaine is the active ingredient in some topical hemorrhoid creams such as Proctosedyl.^[3] It is also a component of the veterinary drug Somulose, used for euthanasia of horses and cattle.

Physical properties

Cinchocaine is relatively insoluble in alkaline aqueous solutions.

See also

• Dibucaine number

Further reading

• Abdel-Ghani NT, Youssef AF, Awady MA . Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry . Farmaco . 60 . 5 . 419–424 . May 2005 . 15910814 . 10.1016/j.farmac.2005.03.001 .
• Souto-Padrón T, Lima AP, ((Ribeiro Rd)) . Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi . Parasitology Research . 99 . 4 . 317–320 . September 2006 . 16612626 . 10.1007/s00436-006-0192-1 . 5933459 .
• Nounou MM, El-Khordagui LK, Khalafallah N . Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles . Acta Poloniae Pharmaceutica . 62 . 5 . 369–379 . 2005 . 16459486 .
• Aroti A, Leontidis E . Simultaneous Determination of the Ionization Constant and the Solubility of Sparingly Soluble Drug Substances. A Physical Chemistry Experiment. . Journal of Chemical Education. 78 . 6 . 786–788 . 2001 . 10.1021/ed078p786 . 2001JChEd..78..786A .

Notes and References

1. Martindale, The Extra Pharmacopoeia, 30th ed, p1006
2. Web site: Dibucaine . MeSH Browser . U.S. National Library of Medicine .
3. Web site: Henderson R . 29 November 2020 . Proctosedyl ointment/suppositories (cinchocaine, hydrocortisone) . Netdoctor . 25 December 2019.