Cimemoxin Explained

Cimemoxin (INN), or cyclohexylmethylhydrazine, is a hydrazine monoamine oxidase inhibitor (MAOI) antidepressant which was never marketed.[1]

Synthesis

It possesses 50 times the relative activity of iproniazid and 25x nialamide (see patent).

3-Cyclohexene-1-carbaldehyde [100-50-5] (aka 1,2,3,6-Tetrahydrobenzaldehyde) is reacted with N-acetylhydrazine to give the hydrazone, which is reduced by catalytic hydrogenation. The acetyl group is removed by acid hydrolysis.

See also

Notes and References

  1. Web site: The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances . . 2011 . 2012-05-20.