Ciliary neurotrophic factor receptor explained

ciliary neurotrophic factor receptor
Hgncid:2170
Symbol:CNTFR
Entrezgene:1271
Omim:118946
Refseq:NM_001842
Uniprot:P26992
Chromosome:9
Arm:p
Band:13

The ciliary neurotrophic factor receptor, also known as CNTFR, binds the ciliary neurotrophic factor. This receptor and its cognate ligand support the survival of neurons.[1] This receptor is most closely related to the interleukin-6 receptor. This receptor possesses an unusual attachment to the cell membrane through a glycophosphatidylinositol linkage.[2]

Notes and References

  1. Davis S, Aldrich TH, Valenzuela DM, Wong VV, Furth ME, Squinto SP, Yancopoulos GD . The receptor for ciliary neurotrophic factor . Science . 253 . 5015 . 59–63 . 1991 . 1648265 . 10.1126/science.1648265 . 1991Sci...253...59D .
  2. Sleeman MW, Anderson KD, Lambert PD, Yancopoulos GD, Wiegand SJ . The ciliary neurotrophic factor and its receptor, CNTFR alpha . Pharm Acta Helv . 74 . 2–3 . 265–72 . 2000 . 10812968 . 10.1016/S0031-6865(99)00050-3.