Ciclafrine Explained

Ciclafrine (; developmental code names Go 3026A, W-43026A) is a sympathomimetic and antihypotensive agent of the phenethylamine family that was never marketed.[1] [2] [3] [4]

Chemistry

Ciclafrine is a substituted phenethylamine and belongs to the class of hemiaminal ethers.

Synthesis

Ciclafrine can be prepared by the reaction of norfenefrine with cycloheptanone.[5]

See also

Notes and References

  1. Book: Elks, J. . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . Springer US . 2014 . 978-1-4757-2085-3 . 2024-08-31 . 271.
  2. Book: Ganellin CR, Triggle DJ . Dictionary of Pharmacological Agents. 21 November 1996. CRC Press. 978-0-412-46630-4. 586–.
  3. Book: Milne, G.W.A. . Drugs: Synonyms and Properties . Taylor & Francis . Routledge Revivals . 2018 . 978-1-351-78990-5 . 31 August 2024 . 325.
  4. Book: Korolkovas A . Essentials of medicinal chemistry. 1988. John Wiley & Sons, Incorporated. 978-0-471-88356-2. 405.
  5. DE. 2336746. 1975-02-13. 2-Hydroxyphenyl-1-oxa-4-azaspiro-alkan-Derivate [2-Hydroxyphenyl-1-oxa-4-azaspiro-alkane derivatives]. Gödecke AG. Satzinger. Gerhard. Herrmann. Manfred.