Ciclafrine Explained

Ciclafrine (INN) is a sympathomimetic phenethylamine and antihypotensive that was never marketed.[1] [2] The compound belongs to the class of hemiaminal ethers.

Synthesis

Ciclafrine can be prepared by the reaction of norfenefrine with cycloheptanone.[3]

Notes and References

  1. Book: Ganellin CR, Triggle DJ . Dictionary of Pharmacological Agents. 21 November 1996. CRC Press. 978-0-412-46630-4. 586–.
  2. Book: Korolkovas A . Essentials of medicinal chemistry. 1988. John Wiley & Sons, Incorporated. 978-0-471-88356-2. 405.
  3. DE. 2336746. 1975-02-13. 2-Hydroxyphenyl-1-oxa-4-azaspiro-alkan-Derivate [2-Hydroxyphenyl-1-oxa-4-azaspiro-alkane derivatives]. Gödecke AG. Satzinger. Gerhard. Herrmann. Manfred.

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