| Official Name: | Chuprene |
| Native Name: | Чупрене |
| Subdivision Type: | Country |
| Subdivision Type1: | Provinces (Oblast) |
| Timezone: | EET |
| Utc Offset: | +2 |
| Timezone Dst: | EEST |
| Utc Offset Dst: | +3 |
| Pushpin Map: | Bulgaria |
| Pushpin Label Position: | right |
| Pushpin Map Caption: | Location of Chuprene |
| Leader Title: | Mayor |
| Postal Code Type: | Postal Code |
| Subdivision Name1: | Vidin |
| Population Total: | 585 |
| Population Footnotes: | http://grao.bg/tna/tab02.txt |
| Population As Of: | 2008 |
| Elevation M: | 556 |
| Postal Code: | 3950 |
| Area Code: | 09327 |
| Coordinates: | 43.5178°N 22.665°W |
| Leader Name: | Vanyo Kostin |
Chuprene (Bulgarian: Чупрене, in Bulgarian pronounced as /ˈt͡ʃuprɛnɛ/) is a village in northwestern Bulgaria, part of Vidin Province. It is the administrative centre of the homonymous Chuprene Municipality, which lies in the southern part of Vidin Province. The village is located 20 kilometres from Belogradchik, 70 kilometres from Vidin, and 13-15 kilometres from the Bulgarian-Serbian border.
Chuprene is situated on the Manastirka and Chuprene rivers in the western Balkan Mountains, at the foot of the Sveti Nikola Mountain and close to Midzhur, the highest peak of the western Balkan Mountains at 2,169 metres. The village is part of the copper ore vein from Bor to Chiprovtsi, and may have been settled by German ("Saxon") ore miners in the Middle Ages. The area has been inhabited since the Bronze Age and was part of the Roman Empire in Antiquity, the First Bulgarian Empire and the Second Bulgarian Empire in medieval times. The village itself was first mentioned in an Ottoman register of the Vidin sanjak of 1454–1455. Jérôme-Adolphe Blanqui mentions it as Chupren in the description of his journey from Belogradchik to Niš in 1841. After the Liberation of Bulgaria, Chuprene grew rapidly and reached a peak population of 1,800–2,000.
The entire population is Christian, Bulgarian Orthodoxy being the dominant confession. Chuprene has a church with a bell and clock tower. The Chuprene Biosphere Reserve is located in the surrounding mountains.
See main article: Chuprene Municipality.
Chuprene municipality includes the following 9 places:
Chuprene Glacier on Smith Island, among South Shetland Islands of the British Antarctic Territory, is named after Chuprene.