Chronotherapy (treatment scheduling) explained

Chronotherapy, also called chronotherapeutics^[1] or chronotherapeutic drug delivery,^[2] refers to the coordination of therapeutic treatments with an individual's circadian or other rhythmic cycles. This may be done to maximize effectiveness of a specific treatment, minimize possible side effects, or both.^{[3] [4]}

In the treatment of psychiatric conditions including bipolar depression,^{[5] [6]} a form of chronotherapy combining intermittent sleep deprivation and morning bright light has shown efficacy and relative tolerability in a number of controlled studies.^{[7] [8] [9]}

See also

• Personalized medicine

Notes and References

1. Web site: Medical dictionary. Merriam-Webster. 6 January 2017.
2. Sajan J . Chronotherapeutics and Chronotherapeutic Drug Delivery Systems. Tropical Journal of Pharmaceutical Research. October 2009. 8. 5. 467–475. 6 January 2017. 1596-5996. ...drug availability is timed to match rhythms of disease in order to optimize therapeutic outcomes and minimize side effects.. 10.4314/tjpr.v8i5.48091. free. 1807/60412. free.
3. Dolgin . Elie . How to ruin cancer's day . Knowable Magazine . 1 May 2018 . 10.1146/knowable-050118-014201 . free . 8 August 2022.
4. Walton . Zandra E. . Altman . Brian J. . Brooks . Rebekah C. . Dang . Chi V. . Circadian Clock's Cancer Connections . Annual Review of Cancer Biology . 4 March 2018 . 2 . 1 . 133–153 . 10.1146/annurev-cancerbio-030617-050216 . 91120424 . 9 August 2022 . en . 2472-3428. free .
5. Benedetti F, Barbini B, Fulgosi MC, Colombo C, Dallaspezia S, Pontiggia A, Smeraldi E . Combined total sleep deprivation and light therapy in the treatment of drug-resistant bipolar depression: acute response and long-term remission rates . The Journal of Clinical Psychiatry . 66 . 12 . 1535–40 . December 2005 . 10.4088/jcp.v66n1207 . 16401154 .
6. Benedetti F, Riccaboni R, Locatelli C, Poletti S, Dallaspezia S, Colombo C . Rapid treatment response of suicidal symptoms to lithium, sleep deprivation, and light therapy (chronotherapeutics) in drug-resistant bipolar depression . The Journal of Clinical Psychiatry . 75 . 2 . 133–40 . February 2014 . 24345382 . 10.4088/JCP.13m08455 .
7. Benedetti F, Barbini B, Colombo C, Smeraldi E . Chronotherapeutics in a psychiatric ward . Sleep Medicine Reviews . 11 . 6 . 509–22 . December 2007 . 17689120 . 10.1016/j.smrv.2007.06.004 .
8. Benedetti F . Antidepressant chronotherapeutics for bipolar depression . Dialogues in Clinical Neuroscience . 14 . 4 . 401–11 . December 2012 . 10.31887/DCNS.2012.14.4/fbenedetti . 23393416 . 3553570 .
9. Dallaspezia S, Suzuki M, Benedetti F . Chronobiological Therapy for Mood Disorders . Current Psychiatry Reports . 17 . 12 . 95 . December 2015 . 26478195 . 10.1007/s11920-015-0633-6 . 39961490 .