Chronic allograft nephropathy explained

Chronic allograft nephropathy
Synonyms:	Sclerosing/chronic allograft nephropathy
Width:	250
Field:	Urology

Chronic allograft nephropathy (CAN) is a kidney disorder which is the leading cause of kidney transplant failure,^[1] occurring months to years after the transplant.

Symptoms and signs

CAN is characterized by a gradual decline in kidney function and, typically, accompanied by high blood pressure and hematuria.^[2]

Pathology

The histopathology is characterized by interstitial fibrosis, tubular atrophy,fibrotic intimal thickening of arteries and glomerulosclerosis.^{[2] [3]}

Diagnosis

CAN is diagnosed by examination of tissue, e.g. a kidney biopsy.^[4]

Notes and References

1. Paul . LC. . Chronic allograft nephropathy: An update. . Kidney Int . 56 . 3 . 783–93 . Sep 1999 . 10.1046/j.1523-1755.1999.00611.x . 10469349 . free .
2. Joosten . SA. . Sijpkens . YW. . van Kooten . C. . Paul . LC. . Chronic renal allograft rejection: pathophysiologic considerations. . Kidney Int . 68 . 1 . 1–13 . Jul 2005 . 10.1111/j.1523-1755.2005.00376.x . 15954891 . free .
3. Nankivell . BJ. . Chapman . JR. . Chronic allograft nephropathy: current concepts and future directions. . Transplantation . 81 . 5 . 643–54 . Mar 2006 . 10.1097/01.tp.0000190423.82154.01 . 16534463 . 30085431 . free .
4. Fletcher . Jeffery T. . Nankivell . Brian J. . Alexander . Stephen I. . Chronic allograft nephropathy . Pediatric Nephrology . Springer Science and Business Media LLC . 24 . 8 . 2009 . 0931-041X . 10.1007/s00467-008-0869-z . 1465–1471. 2697362 .