Christos Ouzounis Explained

Christos Ouzounis
Birth Place:Greece
Birth Name:Christos A. Ouzounis
Fields:Computational Biology
Systems Biomedicine
Bioinformatics
Evolution
Workplaces:European Molecular Biology Laboratory
SRI International
European Bioinformatics Institute[1]
King's College London
Centre for Research & Technology Hellas[2]
Alma Mater:Aristotle University of Thessaloniki (BSc)
University of York (MSc, PhD)
Thesis Title:The role of sequence conservation in the prediction of protein structure.
Thesis Url:https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387193
Thesis Year:1993
Doctoral Advisor:Chris Sander

Christos A. Ouzounis is a computational biologist, a director of research at the CERTH, and Professor of Bioinformatics at Aristotle University in Thessaloniki.[3] [4]

Education

Ouzounis received his undergraduate degree (B.Sc.) in Biological Sciences from the Aristotle University of Thessaloniki (AUTH) in 1987.[3] He then received an M.Sc. in Biological Computation from the University of York in 1988[3] and went on to perform doctoral work with Chris Sander at the European Molecular Biology Laboratory in Heidelberg, Germany receiving his PhD from the University of York in 1993.[3] [5]

Career and research

After his PhD, Ouzounis was a Human Frontiers Science Program (HFSP) Postdoctoral fellow at SRI International, Menlo Park, California. Ouzounis started his own laboratory, researching computational genomics, at the European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI) in 1996.

He then moved his laboratory to King's College London (KCL), as a Professor, Chair and Director of the KCL Centre for Bioinformatics in 2007. Following the restructuring at King's in 2009/2010, he returned to Greece, joining CPERI at CERTH in Thessaloniki. In 2020 he was appointed as Professor of Bioinformatics at AUTH. His research interests include genome structure, function and evolution, evolution of protein function, evolution of genetic information-processing systems, theory and applications of biological sequence comparison, data and knowledge representation for genomics, unsupervised machine learning in very large datasets, biologically-inspired hardware & software engineering (unpublished works), synthetic biology, exobiology, and science communication.

Some of his best known contributions in the field of computational genomics include automated sequence annotation,[6] the discovery of genomic context methods,[7] [8] [9] the inference of metabolic pathways from genome sequences,[10] [11] the development of methods for large-scale clustering of sequence similarities,[12] [13] the definition of the Last Universal Common Ancestor (LUCA) jointly with Nikos Kyrpides,[14] [15] and the quantification of horizontal gene transfer patterns across the "net of life".[16] He also maintains a strong interest in the development of computational biology as an exemplary paradigm in the history of contemporary science,[17] emanating from his first-hand experience that saw bioinformatics grow during the 1990s. He cites as mentors his late father Andreas Ouzounis†, Kostas Kastritsis†, Chris Sander, Antoine Danchin and Carl Woese†.

His former PhD students include David Kreil (2001), Anton Enright (2002) JM Peregrin-Alvarez (2003), Victor Kunin (2004) Nikos Darzentas (2005) and Ignat Drozdov (2010).

Awards and honours

Ouzounis is associate editor for the journal PLOS Computational Biology (since 2007). He is also an associate editor for the journal BioSystems and Honorary Editor for the journal Bioinformatics. He is a founding officer of the International Society for Computational Biology (ISCB), the Mikrobiokosmos initiative (Greece), the Hellenic Society for Computational Biology & Bioinformatics and Hellenic Bioinformatics.[3] He is an active member of the MetaSUB consortium and a board member of Elixir-Europe. He was a visiting professor at the University of Toronto (2011-2014).

He is also a committed adventurer/photographer and a trained RYA windsurfing instructor / amateur windsurfing coach.

Notes and References

  1. Web site: From trees of life to scale-free networks: a new vision for bacterial evolution . European Union, CORDIS . CORDIS, European Union.
  2. Web site: Christos A. Ouzounis Biography .
  3. Web site: Lifeboat foundation Advisory Board.
  4. Web site: Christos Ouzounis's Bibliography. 2019-10-05.
  5. The role of sequence conservation in the prediction of protein structure. . PhD. University of York. Christos. Ouzounis. 1993. 53486615.
  6. Casari. G.. Andrade. M. A.. Bork. P.. Boyle. J.. Daruvar. A.. Ouzounis. C.. Schneider. R.. Tamames. J.. Valencia. A.. Sander. C.. 1995-08-24. Challenging times for bioinformatics. Nature. 376. 6542. 647–648. 10.1038/376647a0. 0028-0836. 7651513. 1995Natur.376..647C. 10993/19513. 25792350 .
  7. Ouzounis. C.. Kyrpides. N.. 1996. The emergence of major cellular processes in evolution. FEBS Letters. 390. 2. 119–123. 10.1016/0014-5793(96)00631-x. 0014-5793. 8706840. 39128865 . free.
  8. Tamames. J.. Casari. G.. Ouzounis. C.. Valencia. A.. 1997. Conserved clusters of functionally related genes in two bacterial genomes. Journal of Molecular Evolution. 44. 1. 66–73. 10.1007/pl00006122. 0022-2844. 9010137. 1997JMolE..44...66T. 26625775 .
  9. Enright . A. J. . Iliopoulos . I.. Kyrpides . N. C.. Ouzounis . C. A.. 10.1038/47056. Protein interaction maps for complete genomes based on gene fusion events . Nature . 402 . 11 . 87–90 . 1999. 10573422 . 1999Natur.402...86E . 4417772 .
  10. Karp. P. D.. Ouzounis. C.. Paley. S.. 1996. HinCyc: A knowledge base of the complete genome and metabolic pathways of H. Influenzae.. Proceedings. International Conference on Intelligent Systems for Molecular Biology. 4. 116–124. 1553-0833. 8877511.
  11. Karp. Peter D.. Ouzounis. Christos A.. Moore-Kochlacs. Caroline. Goldovsky. Leon. Kaipa. Pallavi. Ahrén. Dag. Tsoka. Sophia. Darzentas. Nikos. Kunin. Victor. López-Bigas. Núria. 2005. Expansion of the BioCyc collection of pathway/genome databases to 160 genomes. Nucleic Acids Research. 33. 19. 6083–6089. 10.1093/nar/gki892. 1362-4962. 1266070. 16246909.
  12. Enright . A. J. . van Dongen . S. . Ouzounis . C. A. . 10.1093/nar/30.7.1575. An efficient algorithm for large-scale detection of protein families . Nucleic Acids Research . 30 . 7 . 1575–1584 . 2002 . 11917018 . 101833 .
  13. Kunin. Victor. Ahren. Dag. Goldovsky. Leon. Janssen. Paul. Ouzounis. Christos A.. 2005. Measuring genome conservation across taxa: divided strains and united kingdoms. Nucleic Acids Research. 33. 2. 616–621. 10.1093/nar/gki181. 1362-4962. 548337. 15681613.
  14. Kyrpides. N.. Overbeek. R.. Ouzounis. C.. 1999. Universal protein families and the functional content of the last universal common ancestor. Journal of Molecular Evolution. 49. 4. 413–423. 10.1007/pl00006564. 0022-2844. 10485999. 1999JMolE..49..413K. 14597850 .
  15. Ouzounis. Christos A.. Kunin. Victor. Darzentas. Nikos. Goldovsky. Leon. 2006. A minimal estimate for the gene content of the last universal common ancestor--exobiology from a terrestrial perspective. Research in Microbiology. 157. 1. 57–68. 10.1016/j.resmic.2005.06.015. 0923-2508. 16431085. free.
  16. Kunin. Victor. Goldovsky. Leon. Darzentas. Nikos. Ouzounis. Christos A.. 2005. The net of life: reconstructing the microbial phylogenetic network. Genome Research. 15. 7. 954–959. 10.1101/gr.3666505. 1088-9051. 1172039. 15965028.
  17. Ouzounis. Christos A.. 2012. Rise and demise of bioinformatics? Promise and progress. PLOS Computational Biology. 8. 4. e1002487. 10.1371/journal.pcbi.1002487. 1553-7358. 3343106. 22570600. 2012PLSCB...8E2487O . free .