Chris Dobson Explained

Honorific Prefix:	Sir
Chris Dobson
Birth Name:	Christopher Martin Dobson
Birth Date:	1949 10, df=y
Birth Place:	Rinteln, Lower Saxony, West Germany
Death Place:	Sutton, London, England
Education:	Hereford Cathedral Junior School Abingdon School
Alma Mater:	University of Oxford (MA, DPhil)
Thesis Title:	The conformation of lysozyme in solution
Thesis Url:	http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.453735
Thesis Year:	1975

Sir Christopher Martin Dobson (8 October 1949 – 8 September 2019) was a British chemist, who was the John Humphrey Plummer Professor of Chemical and Structural Biology in the Department of Chemistry at the University of Cambridge, and Master of St John's College, Cambridge.

Early life and education

Dobson was born on 8 October 1949 in Rinteln, Germany, where his father, Arthur Dobson was commissioned as an officer. Both Arthur Dobson and Christopher Dobson's mother, Mabel Dobson (née Pollard), were originally from Bradford in Yorkshire and had left school at age 14. Dobson had two older siblings, Graham and Gillian. Due to his father's postings, Dobson also lived in Lagos, Nigeria.

Christopher Dobson was educated at Hereford Cathedral Junior School, and then Abingdon School from 1960 until 1967.^[1] He completed a Master of Arts and Doctor of Philosophy^[2] at the University of Oxford, where he was a student of Keble College, Oxford and Merton College, Oxford.

Research and career

Dobson's research largely focused on protein folding and protein misfolding, and its association with medical disorders particularly Alzheimer's disease and Parkinson's disease. By applying chemical and biophysical techniques, Dobson investigated links between protein structure, function, and disease.^[3]

He is well known for his serendipitous discovery that ordinary proteins can misfold and aggregate to form amyloid structures.^[4]

Dobson authored and co-authored over 800 papers and review articles,^[5] including 38 in Nature, Science and Cell, which have been cited over 100,000 times. his H-index is 153.

Dobson held research fellowships at Merton College, Oxford and then Linacre College, Oxford before working at Harvard University. He returned to Oxford in 1980 as a Fellow of Lady Margaret Hall, Oxford and as a University Lecturer in Chemistry, later receiving promotions to Reader, then Professor of Chemistry in 1996.

Dobson moved to the University of Cambridge in 2001 as the John Humphrey Plummer Professor of Chemical and Structural Biology. In 2007, he became the Master of St John's College, Cambridge, a post which he held until his death in September 2019.^[6]

In 2012, Dobson founded the Cambridge Centre for Misfolding Diseases, which is currently based in the Chemistry of Health building at the Department of Chemistry at the University of Cambridge.^[7]

In 2016, Chris Dobson co-founded Wren Therapeutics, a biotechnology start-up company whose mission is to find new therapeutics for Alzheimer's disease.^{[8] [3] [9]}

Awards and honours

Dobson was knighted in the 2018 Queen's Birthday Honours for his contributions to science and higher education.^[10] In 2009, Dobson was awarded the Royal Medal by the Royal Society "for his outstanding contributions to the understanding of the mechanisms of protein folding and mis-folding, and the implications for disease", and in 2014 he received both the Heineken Prize for Biochemistry and Biophysics and the Feltrinelli International Prize for Medicine. Dobson was elected a Fellow of the Royal Society (FRS) in 1996.^[11] His nomination reads:

Dobson's other accolades include:

• Corday-Morgan Medal and Prize, The Royal Society of Chemistry, 1981^[12]
• Howard Hughes Medical Institute International Research Scholar, 1992^[12]
• Brunauer Award, American Ceramic Society, 1996^[12]
• Elected a Fellow of the Royal Society (FRS) in 1996^[11]
• Dewey and Kelly Award, University of Nebraska, 1997^[12]
• National Lecturer, American Biophysical Society, 1998^[12]
• Member of the European Molecular Biology Organisation (EMBO) 1999^[12]
• Interdisciplinary Award, The Royal Society of Chemistry, 1999^[12]
• Doctor Honoris Causa, University of Leuven, Belgium, 2001^[12]
• Presidential Visiting Scholar, University of California San Francisco, 2001^[12]
• Bijvoet Medal, Bijvoet Center for Biomolecular Research, University of Utrecht, The Netherlands, 2002^[13]
• Silver Medal, Italian Society of Biochemistry, 2002^[12]
• Royal Society Bakerian Lecturer, 2003^[12]
• Stein and Moore Award, The Protein Society, 2003^[12]
• Honorary Member, National Magnetic Resonance Society of India, 2004^[12]
• Elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2005^[12]
• Honorary Doctor of Medicine, Umea University, Sweden, 2005^[12]
• Davy Medal, The Royal Society, 2005^[12]
• Hans Neurath Award, The Protein Society, 2006^[12]
• Honorary Doctor of Medicine, University of Florence, Italy, 2006^[12]
• Doctor Honoris Causa, University of Liège, Belgium, 2007^[12]
• Sammet Guest Professor, Johann Wolfgang Goethe University, Frankfurt, 2007^[12]
• Foreign Honorary Member of the American Academy of Arts and Sciences, 2007^[12]
• Fellow of the International Society of Magnetic Resonance, 2008^[12]
• Honorary Fellow, Linacre College, University of Oxford, 2008^[12]
• Honorary Fellow, Lady Margaret Hall, University of Oxford, 2008^[12]
• Honorary Fellow, Merton College, University of Oxford, 2009^[12]
• Honorary Fellow, Keble College, University of Oxford, 2009^[12]
• Royal Medal, The Royal Society, 2009^[12]
• Honorary Fellow of the Chemical Council of India, 2010^[12]
• Khorana Award, The Royal Society of Chemistry, 2010^[12]
• Honorary Doctorate of Science, King's College London, 2012^[14]
• Honorary Fellow, Trinity College Dublin, 2013^[15]
• Foreign Associate of the US National Academy of Sciences, 2013^[16]
• Honorary Fellow, Darwin College, University of Cambridge, 2014
• Dr. H.P. Heineken Prize for Biochemistry and Biophysics, Royal Netherlands Academy of Arts and Sciences (KNAW), 2014^[17]
• Antonio Feltrinelli International Prize for Medicine, Accademia Nazionale dei Lincei, Rome, 2014^[18]
• Member of the American Philosophical Society, 2018^[19]

Mentorship

Dobson mentored and supervised many notable PhD students and post-doctoral researchers, many of whom became renowned experts in their own field. These include:

• Carol V. Robinson at the University of Oxford^[20]
• Sheena E. Radford at the University of Leeds^[21]
• Cait MacPhee at the University of Edinburgh^[22]
• Clare Grey at the University of Cambridge^[23]
• Brenda A. Schulman at the Max Planck Institute of Biochemistry in Germany^[24]
• Michele Vendruscolo at the University of Cambridge^{[25] [26]}
• Fabrizio Chiti at the University of Florence^{[27] [28]}

Personal life

Dobson met his wife, Dr Mary Dobson (née Schove) at Merton College at the University of Oxford. They had two sons, Richard and William.

He died on 8 September 2019, from cancer, at Royal Marsden Hospital in Sutton, near Surrey.^[5]

Notes and References

1. Web site: Chemistry Prizes. The Abingdonian.
2. DPhil . Christopher Martin. Dobson . The conformation of lysozyme in solution . University of Oxford . 1975. 500426925 . ora.ox.ac.uk. . Chris Dobson.
3. Robinson . Carol V. . Christopher Dobson, 1949–2019: Mentor, Friend, Scientist Extraordinaire . Annual Review of Biochemistry . 20 June 2020 . 89 . 1 . 1–19 . 10.1146/annurev-biochem-011520-105226 . 32343910 . 216647586 . 28 March 2023 . en . 0066-4154. free .
4. News: Professor Sir Chris Dobson obituary. 12 September 2019. The Times. 13 September 2019. en. 0140-0460.
5. Web site: Professor Sir Christopher Dobson, master of St John's College, Cambridge, dies at 69. 9 September 2019. Cambridge Independent. en. 9 September 2019.
6. Web site: Tributes paid to Master of St John's College who has died age 69. St John's College Cambridge. 9 September 2019.
7. Web site: New research facility for neurodegenerative disorders opened in Cambridge. 21 September 2018. University of Cambridge. en. 9 September 2019.
8. Web site: Knighthood for Prof Christopher Dobson, master of St John's College, in recognition of ground-breaking Alzheimer's research. 8 June 2018. Cambridge Independent. en. 9 September 2019.
9. Web site: Cambridge spinout grabs $23M round to launch a new campaign to tackle protein misfolding. Endpoints News. en. 9 September 2019.
10. Web site: Knighthood for eminent scientist Sir Christopher Dobson. Lady Margaret Hall. en. 9 September 2019.
11. Web site: Sir Christopher Dobson FMedSci FRS. Anon. 1996. Royal Society. London. royalsociety.org. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
12. Web site: Chris Dobson – CV. 11 September 2019.
13. Web site: Bijvoet Medal. Bijvoet Center for Biomolecular Research. 12 September 2017. https://web.archive.org/web/20170912191415/http://bijvoet-center.eu/bijvoet-medal/. 12 September 2017. dead.
14. Web site: Master receives Honorary Degree from King's College London | StJohns.
15. Web site: Fellows & Scholars : Trinity College Dublin, the University of Dublin, Ireland.
16. Web site: 2013 NAS Members and Foreign Associates Elected.
17. Web site: Christopher M. Dobson – KNAW . 26 June 2014 . 3 March 2016 . https://web.archive.org/web/20160303210614/http://knaw.nl/en/awards/laureates/dr-h-p-heinekenprijs-voor-biochemie-en-biofysica/christopher-m-dobson?set_language=en . dead .
18. Web site: Feltrinelli International Prize awarded to Chris Dobson | Department of Chemistry.
19. Web site: Election of New Members at the 2018 Spring Meeting | American Philosophical Society.
20. Web site: Paying tribute to Chris Dobson. www.rsc.org. en-GB. 16 September 2019.
21. Web site: Membership to Royal Society. en-GB. 27 September 2019.
22. Cait MacPhee. Cait MacPhee. sciorama. 1172416493998366722. 13 September 2019. Chris Dobson was a vocal and practical advocate of women in science before it was cool. The number of women he employed or appointed in Oxford led to us being called "Dobettes" (yes, we knew what you called us, you pricks).. en.
23. Web site: Membership to Royal Society of Chemistry. en-GB. 6 October 2019.
24. Web site: Membership to the National Academy of Sciences of the US.
25. Web site: Membership to Academia Europaea. en-GB. 27 September 2019.
26. Web site: Citation metrics at Scopus. en-GB. 27 September 2019.
27. Web site: Membership to Academia Europaea. en-GB. 6 October 2019.
28. Web site: Citation metrics at Scopus. en-GB. 6 October 2019.