| Consort: | yes |
| Christiane Charlotte of Nassau-Ottweiler | |
| Succession: | Landgravine consort of Hesse-Homburg |
| Reign: | 17 October 1728 – 8 June 1746 |
| House: | House of Nassau |
| Father: | Frederick Louis, Count of Nassau-Ottweiler |
| Mother: | Countess Christiane of Ahlefeldt-Rixingen |
| Spouse: | Charles Louis, Count of Nassau-Saarbrücken Frederick III, Landgrave of Hesse-Homburg |
| Birth Place: | Ottweiler |
| Death Place: | Bad Homburg |
Christiane Charlotte of Nassau-Ottweiler (2 September 1685 – 6 November 1761) was a Countess of Nassau-Ottweiler by birth and by marriage successively Countess of Nassau-Saarbrücken and countess of Hesse-Homburg.
Christiane Charlotte was a daughter of the Count Frederick Louis of Nassau-Ottweiler (1651–1728) from his first marriage with Countess Christiane of Ahlefeldt (1659–1695).
She married her first husband, Count Charles Louis of Nassau-Saarbrücken, on 22 April 1713 in Saarbrücken:
She closed her second marriage on 17 October 1728 in Saarbrücken with Landgrave Frederick III of Hesse-Homburg. This marriage came into existence after mediation by Frederick's brother, Landgrave Ernest Louis of Hesse-Darmstadt. This marriage should consolidate the ailing finances of Hesse-Homburg. An imperial debit commission had found only two silver spoons at the court. Frederick III had raised concerns and proposed to inform his bride-to-be, who demanded a proper dower, about his financial situation. Ernest Louis then wrote to Frederick : "Write brother, write, as long as you have time, you can do so."
From her first marriage, Christiane Charlotte had two sons, who, however, both died in infancy: