Christian Hamel Explained

Christian Hamel (4 October 1955 – 15 August 2017) was a French Professor at the Institute for Neurosciences of Montpellier, Hôpital Saint Eloi (INM) research unit INSERM 583 of the University. He studied transduction, integration and disorders of sensory and motor systems with the ultimate goal of finding treatments for degeneration of the retina and optic nerve.[1]

Hamel discovered and described in 1993 the RPE65 protein.[2] [3] Retinal pigment epithelium-specific 65 kDa protein is an enzyme in the vertebral visual pigment.[4] The next year he mapped the RPE65 gene to human chromosome 1 (mouse chromosome 3) and refined it to 1p31 by fluorescence in situ hybridization.[5] His research interests were to find the causes of inherited diseases of the retina and optic nerve.[6]

Notes and References

  1. News: A Montpellier, les 10 chercheurs les plus en pointe . In Montpellier, the 10 most advanced researchers . French . LExpansion . 12 October 2011 .
  2. Hamel . C. P. . Tsilou . E. . Harris . E. . Pfeffer . B. A. . Hooks . J. J. . Detrick . B. . Redmond . T. Michael . A developmentally regulated microsomal protein specific for the pigment epithelium of the vertebrate retina . Journal of Neuroscience Research . 1 March 1993 . 34 . 4 . 414–425 . 10.1002/jnr.490340406 . 8474143 .
  3. Hamel . CP . Tsilou . E . Pfeffer . BA . Hooks . JJ . Detrick . B . Redmond . TM . Molecular cloning and expression of RPE65, a novel retinal pigment epithelium-specific microsomal protein that is post-transcriptionally regulated in vitro. . The Journal of Biological Chemistry . 25 July 1993 . 268 . 21 . 15751–7 . 10.1016/S0021-9258(18)82319-5 . free . 8340400 .
  4. Cai . Xue . Conley . Shannon M. . Naash . Muna I. . RPE65: Role in the visual cycle, human retinal disease, and gene therapy . Ophthalmic Genetics . 2009 . 30 . 2 . 57–62 . 10.1080/13816810802626399 . 19373675 . 2821785 .
  5. Hamel . Christian P. . Jenkins . Nancy A. . Gilbert . Debra J. . Copeland . Neal G. . Redmond . T.Michael . The Gene for the Retinal Pigment Epithelium-Specific Protein RPE65 Is Localized to Human 1p31 and Mouse 3 . Genomics . April 1994 . 20 . 3 . 509–512 . 10.1006/geno.1994.1212 . 8034329 .
  6. Web site: Hamel, Christian . European Vision Institute .

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