| Chris Best | |
| Number: | 66 |
| Position1: | Guard |
| Birth Date: | 3 April 1983 |
| Birth Place: | Calgary, Alberta |
| Height Ft: | 6 |
| Height In: | 5 |
| Weight Lbs: | 301 |
| Cfldraftedyear: | 2005 |
| Cfldraftedround: | 1 |
| Cfldraftedpick: | 4 |
| Cfldraftedteam: | Saskatchewan Roughriders |
| Playing Years1: | – |
| Playing Team1: | Saskatchewan Roughriders |
| Import: | n |
| Cfl-Archive: | https://web.archive.org/web/20150512003232/http://www.cfl.ca/roster/show/id/2239 |
Chris Best (born April 3, 1983) is a former Canadian football guard who played 10 seasons for the Saskatchewan Roughriders of the Canadian Football League. He played CIS Football at Waterloo, as well as playing four seasons in the United States at Duke University. He graduated from Duke University in 2005 with a degree in Mechanical Engineering, and is currently finishing his master's degree from the University of Waterloo.
He won the 101st Grey Cup with the Roughriders in 2013.