Chondroitin AC lyase explained
chondroitin AC lyase |
Ec Number: | 4.2.2.5 |
Cas Number: | 9047-57-8 |
Go Code: | 0030341 |
The enzyme chondroitin AC lyase catalyzes the chemical reaction
Eliminative degradation of polysaccharides containing 1,4-β-D-hexosaminyl and 1,3-β-D-glucuronosyl linkages to disaccharides containing 4-deoxy-β-D-gluc-4-enuronosyl groups
This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on polysaccharides. The systematic name of this enzyme class is chondroitin AC lyase. Other names in common use include chondroitinase (ambiguous), chondroitin sulfate lyase, chondroitin AC eliminase, chondroitin AC lyase, chondroitinase AC, and ChnAC.
Structural studies
As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,, and .
References
- NAKADA HI, WOLFE JB . 1961 . Studies on the enzyme chondroitinase: product structure and ion effects . . 94 . 244 - 51 . 13727579 . 10.1016/0003-9861(61)90037-6 . 2 .
- Pojasek K, Shriver Z, Kiley P, Venkataraman G, Sasisekharan R . 2001 . Recombinant expression, purification, and kinetic characterization of chondroitinase AC and chondroitinase B from Flavobacterium heparinum . . 286 . 343 - 51 . 11500043 . 10.1006/bbrc.2001.5380 . 2 .
- Cygler M . Crystallization and preliminary analysis of chondroitinase AC from Flavobacterium heparinum . . 54 . 279 - 80 . 9761894 . 10.1107/S0907444997009037 . Shilton . BH . Li . Y . Allaire . M . Laliberté . M . Eggimann . B . Cygler . M . 1998. Pt 2 .
- Lauder RM . 2005 . Characterization of oligosaccharides from the chondroitin/dermatan sulfates. 1H-NMR and 13C-NMR studies of reduced trisaccharides and hexasaccharides . . 272 . 6276 - 86 . 16336265 . 10.1111/j.1742-4658.2005.05009.x . Nieduszynski . IA . Giannopoulos . M . Weeks . SD . Sadler . IH . Lauder . RM . 24 . 40325628 . free .