| choline-phosphate cytidylyltransferase | |
| Ec Number: | 2.7.7.15 |
| Cas Number: | 9026-34-0 |
| Go Code: | 0004105 |
Choline-phosphate cytidylyltransferase is an enzyme that catalyzes the chemical reaction
CTP + choline phosphate
\rightleftharpoons
where the two substrates of this enzyme are CTP and choline phosphate, and the two products are diphosphate and CDP-choline. It is responsible for regulating phosphatidylcholine content in membranes.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:choline-phosphate cytidylyltransferase. Other names in common use include phosphorylcholine transferase, CDP-choline pyrophosphorylase, CDP-choline synthetase, choline phosphate cytidylyltransferase, CTP-phosphocholine cytidylyltransferase, CTP:phosphorylcholine cytidylyltransferase, cytidine diphosphocholine pyrophosphorylase, phosphocholine cytidylyltransferase, phosphorylcholine cytidylyltransferase, and phosphorylcholine:CTP cytidylyltransferase. This enzyme participates in aminophosphonate metabolism and glycerophospholipid metabolism.
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .