Cho Yoon-kyoung explained

Fields:Lab-on-a-chip, microfluidics, biosensors, translational research, basic research, nanomedicine
Workplaces:IBS (Institute for Basic Science)
UNIST (Ulsan National Institute of Science and Technology)
SAIT (Samsung Advanced Institute of Technology)
UIUC (University of Illinois at Urbana–Champaign)
POSTECH (Pohang University of Science and Technology)
Alma Mater:University of Illinois at Urbana–Champaign, POSTECH
Thesis Title:Structure and Dynamics of Confined Molecules
Thesis Url:https://search.proquest.com/docview/304507049
Thesis Year:1999
Doctoral Advisor:Steve Granick
Academic Advisors:Lee Kun-Hong
Known For:Lab-on-a-disc, biomedical engineering
Spouses:)-->
Partners:)-->
Website:https://fruits.unist.ac.kr
Module:
Hangul:조윤경
Rr:Jo Yun-Gyeong
Mr:Cho Yun-Kyŏng
Child:yes

Cho Yoon-Kyoung is an interdisciplinary researcher involved in basic science to translational research in microfluidics and nanomedicine. She is a group leader in the Center for Soft and Living Matter at the Institute for Basic Science (IBS) and a full professor in Biomedical Engineering at the Ulsan National Institute of Science and Technology (UNIST), Ulsan, Korea.[1] Cho is a member of the National Academy of Engineering of Korea[2] [3] and a Fellow of the Royal Society of Chemistry.[4]

Education

Cho majored in chemical engineering at the Pohang University of Science and Technology (POSTECH) graduating with B.S. and M.S. in 1992 and 1994, respectively. She completed her Ph.D. in materials science and engineering at the University of Illinois at Urbana–Champaign in 1999, her advisor was Steve Granick.

Career

She worked at the Samsung Advanced Institute of Technology as a senior researcher from 1999 until 2008[5] where she participated in developing in vitro diagnostic devices with biomedical applications.[6]

Joining the Ulsan National Institute of Science and Technology (UNIST) in 2008, she became the chair of the School of Nano-Bioscience and Chemical Engineering (2008–2014) and later the chair of the School of Life Sciences (2014–2015) and the director of World Class University (2009–2013) and Brain Korea 21 (2013–2015) programs. She has been a group leader in the Institute for Basic Science Center for Soft and Living Matter since 2015. From 2016, she is a full professor in the Department of Biomedical Engineering in UNIST[7] [1]

She has been an associate editor of Lab on a Chip from 2019[8] and previously served as an editorial board member (2013-2019). She also has been an advisory board member for Analyst[9] and an editorial board member for Micromachines. In addition, she has been a board member of the Chemical and Biological Microsystems Society (CBMS).[10]

She served as a member for Presidential Advisory Council on Science & Technology (2018)[11] and advisory committee member for the Ministry of Personnel Management (2018).[12]

Research and achievements

Much of Cho's research has focused on centrifugal microfluidics.[13] Cho and her team have developed lab-on-a-disc systems to provide a “sample-in and answer-out” type biochemical analysis solution with simple, size-reduced, and cost-efficient instrumentation.[14] She demonstrated fully integrated virus enrichment and nucleic acids extraction on a chip,[15] fully automated immunoassay,[16] [17] [18] label-free isolation of circulating tumor cells,[19] [20] size fractionization of extracellular vesicles (EVs),[21] [22] RNA detection from urinary EVs,[23] and electricity-free bacteria enrichment for urinary tract infection detection and rapid antimicrobial susceptibility test[24] by directly testing clinical samples of patients, which allows high precision detection of biomarkers for monitoring the efficacy of therapy and emergent drug resistance for personalized medicine. In 2021, her research team was the first to program exosomes for the purpose of energy generation in living cells.[25]

The other key area of Cho's research concerns microfluidic systems to understand intercellular communication. Biomimetic chips such as platelet chips[26] or 3D human liver-on-a-chip[27] have been designed to study the roles of EVs in cancer metastasis. She investigated morphological adaptations and mechanobiological behaviors of epithelial cells on a torus surface.[28] In addition, her group is interested in nanomaterials, nanodevices, and nanofluidics which can provide nonconventional tools and platforms to enhance biosensing characteristics or to investigate physical, chemical, and biological properties of living matter.[29]

Awards and honors

Cho was elected Member of the National Academy of Engineering of Korea in 2020.[5] [2] She is a Fellow of Royal Society of Chemistry.[4] Her work has been recognized by multiple awards, including National Top 100 R&D Performances (2019[30] and 2023[31]), Korea's Top 5 Bio-field research outcome (2017, 2020), Faculty of the Year Award (UNIST, 2012 and 2020), Korean Woman Engineer of the Year (2010), SAMSUNG CEO's Award for Best Technology Achievement of the Year (2004, 2007), the Racheff Award for Outstanding Graduate Research (UIUC, 1998),[32] and invited lectures at the Nobel Symposium on Microfluidics in Sweden (2017),[33] and plenary seminar at MicroTAS 2010.[34]

Selected publications

External links

Notes and References

  1. Web site: LIVING SYSTEMS: Cho, Yoon Kyoung . . Center for Soft and Living Matter . 20 January 2021 .
  2. Web site: 최영록·조윤경 교수, 한국공학한림원 2021년 신입 회원 선정 . 양윤정 . 11 January 2021 . . 20 January 2021 . Korean.
  3. Web site: 공학한림원 일반회원에 조윤경 그룹리더 선정 . . 6 January 2021 . Institute for Basic Science . 4 March 2021 . Korean.
  4. Web site: Yoon-Kyoung Cho's Biography . . Microfluidics, Circulating Biomarkers & Exosomes Asia Seoul, Korea . Select Biosciences. 13 July 2020 .
  5. Um . Eujin . Oh . Jung Min . Granick . Steve . Steve Granick . Cho . Yoon-Kyoung . 21 September 2017 . Cell migration in microengineered tumor environments . Lab on a Chip . 24 . 4171–4185 . 10.1039/C7LC00555E.
  6. ">Web site: New Associate Editor: Yoon-Kyoung Cho . Sian Carrington . 19 February 2019 . Lab on a Chip Blog . 20 January 2021 . We are delighted to announce that Professor Yoon-Kyoung Cho (UNIST, South Korea) has been appointed Associate Editor for Lab on a Chip..
  7. Web site: Researcher Page Cho, Yoon-Kyoung (조윤경) . . Scholar Works at UNIST . UNIST . 20 January 2021 .
  8. Web site: Lab on a Chip Editorial Board Members . . . 9 July 2020 .
  9. Web site: Advisory Board . . . 9 July 2020 .
  10. Web site: Current Officers & Directors . . Chemical and Biological Microsystems Society . 4 February 2021 .
  11. Web site: 심의위원 . . Presidential Advisory Council on Science & Technology . 4 February 2021 . Korean.
  12. Web site: 정부 '공직인사혁신위원회' 10일 출범 . 부애리 . 아시아경제 . 4 February 2021 . Korean.
  13. Gorkin . Robert . Park . Jiwoon . Siegrist . Jonathan . Amasia . Mary . Lee . Beom Seok . Park . Jong-Myeon . Kim . Jintae . Kim . Hanshin . Madou . Marc . Cho . Yoon-Kyoung . 28 May 2010 . Centrifugal microfluidics for biomedical applications . Lab Chip . 10 . 14 . 1758–1773 . Royal Society of Chemistry . 10.1039/B924109D. 1802.05610 .
  14. Park . Jong-Myeon . Cho . Yoon-Kyoung . Lee . Beom-Seok . Lee . Jeong-Gun . Ko . Christopher . 2007 . Multifunctional microvalves control by optical illumination on nanoheaters and its application in centrifugal microfluidic devices . Lab on a Chip . 7 . 5 . 557–564 . Royal Society of Chemistry. 10.1039/B616112J.
  15. Cho . Yoon-Kyoung . Lee . Jeong-Gun . Park . Jong-Myeon . Lee . Beom-Seok . Lee . Youngsun . Ko . Christopher . 2007 . One-step pathogen specific DNA extraction from whole blood on a centrifugal microfluidic device . Lab on a Chip . 7 . 5 . 565–573 . 10.1039/B616115D . Royal Society of Chemistry.
  16. Lee . Beom Seok . Lee . Jung-Nam . Park . Jong-Myeon . Lee. Jeong-Gun . Kim . Suhyeon . Cho . Yoon-Kyoung . Ko . Christopher . 2009 . A fully automated immunoassay from whole blood on a disc . Lab on a Chip . 9 . 11 . 1548–1555 . 10.1039/b820321k . Royal Society of Chemistry.
  17. Lee . Beom Seok . Lee . Yang Ui . Kim . Han-Sang . Kim . Tae-Hyeong . Park . Jiwoon . Lee . Jeong-Gun . Kim. Jintae . Kim . Hanshin . Lee . Wee Gyo . Cho . Yoon-Kyoung . 2011 . Fully integrated lab-on-a-disc for simultaneous analysis of biochemistry and immunoassay from whole blood . Lab on a Chip . 11 . 1 . 70–78 . Royal Society of Chemistry . 10.1039/C0LC00205D.
  18. Park. Jiwoon . Sunkara. Vijaya . Kim. Tae-Hyeong . Hwang . Hyundoo . Cho . Yoon-Kyoung . 2012 . Lab-on-a-Disc for Fully Integrated Multiplex Immunoassays . Analytical Chemistry . 84 . 10 . 2133–2140 . 10.1021/ac300979f. free .
  19. Kim. Tae-Hyeong . Park . Juhee . Lim. Minji . Oh. Jung Min . Kim . Hyeongeun . Jeong. Hyunjin . Lee. Sun Ju . Park . Hee Chul . Jung. Sungmok . Kim . Byung Chul . Lee . Kyusang . Kim . Mi-Hyun . Park . Do Youn . Kim . Gwang Ha . Cho . Yoon-Kyoung . 2017 . FAST: size-selective, clog-free isolation of rare cancer cells from whole blood at a liquid-liquid interface . Analytical Chemistry . 89 . 2. 1155–1162. 10.1021/acs.analchem.6b03534.
  20. Limi . Minji . Parki . Juhee . Lowe . Alarice C.. Jeong . Hyoung-oh . Lee. Semin . Park. Hee Chul . Lee . Kyusang . Kim . Gwang Ha . Kim. Mi-Hyun . Cho . Yoon-Kyoung . 2020 . A Lab-on-a-Disc platform enables serial monitoring of individual CTCs associated with tumor progression during EGFR-targeted therapy for patients with NSCLC . Theranostics . 10 . 5181–5194 . 10.7150/thno.44693. 7196290 .
  21. Woo. Hyun-Kyung . Sunkara. Vijaya . Park . Juhee . Kim . Tae-Hyeong . Han . Ja-Ryoung . Kim . Chi-Ju . Choi . Hyun-Il . Kim . Yoon-Keun . Cho. Yoon-Kyoung . 2017 . Exodisc for rapid, size-selective, and efficient isolation and analysis of nanoscale extracellular vesicles from biological samples . ACS Nano . 11 . 2 . 1360–1370 . 10.1021/acsnano.6b06131.
  22. Sunkara . Vijaya . Kim . Chi-Ju . Park . Juhee . Woo . Hyun-Kyung . Kim . Dongyoung . Ha. Hong Koo . Kim . Mi-Hyun . Son. Youlim . Kim . Jae-Ryong . Cho . Yoon-Kyoung . 2019 . Fully automated, label-free isolation of extracellular vesicles from whole blood for cancer diagnosis and monitoring . Theranostics . 9 . 1851–1863 . 10.7150/thno.32438 . 6485293 .
  23. Woo . Hyun-Kyung . Park. Juhee . Ku . Ja Yoon . Lee. Chan Ho . Sunkara . Vijaya . Ha . Hong Koo . Cho . Yoon-Kyoung . Urine-based liquid biopsy: Non-invasive and sensitive AR-V7 detection in urinary EVs from patients with prostate cancer . Lab on a Chip . 19 . 1 . 87–97 . 10.1039/C8LC01185K.
  24. Michael . Issac . Kim . Dongyoung . Gulenko . Oleksandra . Kumar . Sumit . Kumar . Saravana . Clara . Jothi . Ki . Dong Yeob . Park. Juhee . Jeong . Hyun Yong . Kim. Taek Soo . Kwon . Sunghoon . Cho . Yoon-Kyoung . 2020 . A fidget spinner for the point-of-care diagnosis of urinary tract infection . Nature Biomedical Engineering . 4. 591–600 . 10.1038/s41551-020-0557-2.
  25. Kumar . Sumit . Karmacharya . Mamata . Michael . Issac J. . Choi . Yongjun . Kim . Junyoung . Kim . InUn . Cho . Yoon-Kyoung . 13 September 2021 . Programmed exosome fusion for energy generation in living cells . Nature Catalysis . 763–774 . 10.1038/s41929-021-00669-z.
  26. Kumar . Sumit . Han . Jae‐A . Michael . Issac J. . Ki . Dongyeob . Sunkara. Vijaya . Park . Juhee . Gautam . Shreedhar . Ha . Hong Koo . Zhang. Liangfang . Cho . Yoon-Kyoung . 2019 . Human platelet membrane functionalized microchips with plasmonic codes for cancer detection . Advanced Functional Materials . 29 . 30. 1902669 . 10.1002/adfm.201902669.
  27. Kim . Junyoung . Lee . Chaeeun . Kim . Inun . Ro . Jooyoung . Kim . Jungmin . Min . Yoohong . Park . Juhee . Sunkara . Vijaya . Park . Yang-Seok . Michael . Issac . Kim . Young-Ae . Lee . Hee Jin . Cho . Yoon-Kyoung . 2020 . Three-dimensional Human Liver-chip Emulating Pre-metastatic Niche Formation by Breast Cancer-derived Extracellular Vesicles . ACS Nano . 14 . 11 . 14971–14988 . 10.1021/acsnano.0c04778.
  28. Yu . Sun-Min . Li . Bo . Amblard . Francois . Granick . Steve . Steve Granick . Cho . Yoon-Kyoung . 2020 . Adaptive architecture and mechanoresponse of epithelial cells on a torus . Biomaterials . 265 . 120420 . 10.1016/j.biomaterials.2020.120420. 0142-9612 .
  29. Web site: IBS Center for Soft and Living Matter, UNIST-Biomedical Engineering: . . Fruits Lab . 5 February 2021 .
  30. Web site: Three UNIST R&D Outcomes Selected for National Top 100 R&D Performances: Research breakthroughs by Professors Kwanyong Seo, Yoon-Kyoung Cho, and Sang-Young Lee, selected for 2019 National Top R&D Performances . Heo . JooHyeon . 14 October 2019 . News Center . . 9 July 2020 .
  31. Web site: [용의 해 밝히는 한국과학]② 美에서 사기로 끝난 ‘피 한 방울 암 진단’, 한국이 해냈다 ]. 홍아름 . 1 January 2024 . . . 2 January 2024 . Korean.
  32. Web site: FRUITS Lab People . . FRUITS Lab . 25 February 2021 .
  33. Microfluidics: Proceedings of the 162nd Nobel Symposium . 5–8 June 2017 . 162nd Nobel Symposium . Johan . Irmeli . Thomas . Elf . Barkefors . Lurell . Microfluidics . Stockholm, Sweden . 39 . PDF . 25 February 2021 .
  34. Web site: Keynote Speakers . . The Chemical and Biological Microsystems Society . 25 February 2021 .

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