Chlorproguanil/dapsone explained

Type:combo
Component1:Chlorproguanil
Class1:Antimalarial drug
Component2:Dapsone
Class2:Antibiotic
Legal Status:Withdrawn
Cas Number:209665-78-1

Chlorproguanil/dapsone (sold commercially as Lapdap) was a fixed dose antimalarial combination containing chlorproguanil and dapsone,[1] which act synergistically against malaria. The drug was withdrawn in 2008 following increasing evidence of toxicity in the form of haemolysis occurring in patients with G6PD deficiency.[2]

Notes and References

  1. Lang T, Greenwood B . The development of Lapdap, an affordable new treatment for malaria . The Lancet. Infectious Diseases . 3 . 3 . 162–8 . March 2003 . 12614733 . 10.1016/S1473-3099(03)00547-4 .
  2. Luzzatto L . 34866078 . The rise and fall of the antimalarial Lapdap: a lesson in pharmacogenetics . Lancet . 376 . 9742 . 739–41 . August 2010 . 20599264 . 10.1016/S0140-6736(10)60396-0 .