Chlorophenylsilatrane Explained

1-(4-Chlorophenyl)silatrane is an extremely toxic[1] organosilicon compound which was developed by M&T Chemicals as a single-dose rodenticide.[2] It was never registered as rodenticide,[1] except for experimental use. 1-(4-Chlorophenyl)silatrane was one of the chemicals studied in the Project Coast.[3] [4]

Toxicity

1-(4-Chlorophenyl)silatrane is a GABA receptor antagonist[5] and it destroys nervous functions in the central nervous system of vertebrates, primarily in the brain and possibly in the brain stem.[6] [7] [8] It's a rapid acting convulsant, causing convulsions within 1 minute in mice and rats. Death occurred within 5 minutes.[9] It is therefore likely to induce poison shyness. In field trials, it was less effective than zinc phosphide against wild rats.[10]

See also

Notes and References

  1. Lund . M. . New Rodenticides Against Anticoagulant-resistant Rats and Mice . EPPO Bulletin . Wiley . 7 . 2 . 1977 . 0250-8052 . 10.1111/j.1365-2338.1977.tb02750.x . 503–508.
  2. Crabtree . D. Glen . Beiter . Charles B. . Schwarcz . Morton . 5-p-Chlorophenyl silatrane, a new single-dose rodenticide . Chemical Report by M&T Chemicals Inc. . 1970 .
  3. Web site: South Africa Chemical Chronology . . 2005-04-23 . NTI.org . Nuclear Threat Initiative . 2020-07-31.
  4. Bale . Jeffrey M. . South Africa's Project Coast: "Death Squads," Covert State-Sponsored Poisonings, and the Dangers of CBW Proliferation . Democracy and Security . Informa UK Limited . 2 . 1 . 2006 . 1741-9166 . 10.1080/17419160600623434 . 27–59. 143175071 .
  5. Casida . JE . Lawrence . LJ . Structure-activity correlations for interactions of bicyclophosphorus esters and some polychlorocycloalkane and pyrethroid insecticides with the brain-specific t-butylbicyclophosphorothionate receptor . Environmental Health Perspectives . September 1985 . 61 . 123–32 . 2415350 . 1568750 . 10.2307/3430066. 3430066 .
  6. Casida . John E. . Eto . Morifusa . Moscioni . A.David . Engel . Judith L. . Milbrath . Dean S. . Verkade . John G. . Structure-toxicity relationships of 2,6,7-trioxabicyclo[2.2.2]-octanes and related compounds . Toxicology and Applied Pharmacology . Elsevier BV . 36 . 2 . 1976 . 0041-008X . 10.1016/0041-008x(76)90006-5 . 261–279. 1084063 . 1976ToxAP..36..261C .
  7. Proceedings of the International Society of Neurochemistry . Mattson . H. . Brandt . K. . Heilbronn . E. . 21–26 August 1977 . 56 . Copenhagen, Denmark . Sixth International Meeting of the International Society for Neurochemistry .
  8. Book: Voronkov, Michail G. . Topics in Current Chemistry . Biological activity of silatranes . 1979 . 84 . Springer-Verlag . Berlin/Heidelberg . 3-540-09347-8 . 10.1007/bfb0048523 . 77–135. 388722 .
  9. Greaves . JH . Redfern . R . Tinworth . H . Laboratory tests of 5-p-chlorophenyl silatrane as a rodenticide . The Journal of Hygiene . August 1974 . 73 . 1 . 39–43 . 4529452 . 2130561 . 10.1017/s0022172400023810.
  10. Rennison . B. D. . Field trials of the rodenticide 5-p-chlorophenyl silatrane against wild rats (Rattus norvegicus Berk.) . Journal of Hygiene . Cambridge University Press . 73 . 1 . 1974 . 0022-1724 . 10.1017/s0022172400023822 . 45–48 . 4529041 . 2130558 .

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