Chlorohydroxyphenylglycine Explained

2-Chloro-5-hydroxyphenylglycine or CHPG is an agonist of the metabotropic glutamate receptors, specific for mGluR5.[1]

It is capable of directly potentiating the depolarization of hippocampal CA1 neurons induced through NMDA administration.[2]

Notes and References

  1. 10.1186/1471-2210-12-6 . The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency . 2012 . Kammermeier . Paul J . BMC Pharmacology . 12 . 6 . 22642439 . 3416681 . free .
  2. Collingridge G.. Volianskis A.. Bannister N.. France G.. Hanna L.. Mercier M.. Tidball P.. Fang G.. Irvine M.. The NMDA receptor as a target for cognitive enhancement. Neuropharmacology. 64. 13–26. 2013 . 22796429. 10.1016/j.neuropharm.2012.06.051. Costa. Blaise M.. Monaghan. Daniel T.. Bortolotto. Zuner A.. Molnár. Elek. Lodge. David. Jane. David E.. 4696548.

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