Chlormerodrin Explained
| Iupac Name: | 3-carbamoylamino-2-methoxypropylmercury(II) chloride |
| Legal Us Comment: | Withdrawn |
| Cas Number: | 62-37-3 |
| Unii: | 99T5TWO621 |
| Atc Prefix: | none |
| Pubchem: | 25210 |
| Chembl: | 2110562 |
| Chemspiderid: | 2615 |
| Drugbank: | DB00534 |
| Chebi: | 59445 |
| C: | 5 |
| H: | 11 |
| Cl: | 1 |
| Hg: | 1 |
| N: | 2 |
| O: | 2 |
| Smiles: | COC(CNC(=O)N)C[Hg]Cl |
| Stdinchi: | 1S/C5H11N2O2.ClH.Hg/c1-4(9-2)3-7-5(6)8;;/h4H,1,3H2,2H3,(H3,6,7,8);1H;/q;;+1/p-1 |
| Stdinchikey: | BJFGVYCULWBXKF-UHFFFAOYSA-M |
Chlormerodrin is a mercurial diuretic commercially traded from 1952[1] until 1974[2] that was once used to treat patients with heart failure,[3] but is no longer in widespread use.[4] The radiolabelled form (197Hg & 203Hg) had also been used for medical imaging of the kidney and brain[5] [6] and the 197Hg form was even considered a contender for 99mTc by some physicians,[7] but was ultimately discontinued by the FDA in 1989.[8]
Notes and References
- Encyclopedia: Sittig M . Pharmaceutical Manufacturing Encyclopedia . Noyes Publications . Westwood . 1988 .
- Crout JR . Fixed combination prescription drugs: FDA policy . Journal of Clinical Pharmacology . 14 . 5–6 . 249–254 . 1974 . 4829517 . 10.1002/j.1552-4604.1974.tb02309.x . 5830209 .
- Leff WA, Nussbaum HE . Chlormerodrin: clinical effectiveness and absence of toxicity in congestive heart failure; report of a four-year study . British Medical Journal . 1 . 5126 . 883–889 . April 1959 . 13629153 . 1992943 . 10.1136/bmj.1.5126.883 .
- Web site: PubChem . U.S. National Library of Medicine . Chlormerodrin. 2021-09-23 . en.
- Sodee DB, Di Stefano B . The Clinical Value of Today's Radioisotope Scanning . The Ohio State Medical Journal . 61 . 819–22 . September 1965 . 14340215 .
- Yamamoto YL, Feindel W, Zanelli J . Comparative study of radioactive chlormerodrin (Neohydrin) tagged with mercury 197 and mercury 203 for brain scanning . Neurology . 14 . 9 . 815–820 . September 1964 . 14215595 . 10.1212/wnl.14.9.815 . 43526449 .
- Sodee DB . Comparison of 99mTc-pertechnetate and 197Hg-chlormerodrin for brain scanning . Journal of Nuclear Medicine . 9 . 12 . 645 . December 1968 . 5729215 .
- FDA, Approved Drug Products with Therapeutic Equivalence Evaluations, US Department Of Health And Human Service, 1989.
