Chlorcyclizine Explained

Chlorcyclizine (Di-Paralene, Mantadil, Pruresidine, Trihistan) is a first-generation antihistamine of the diphenylmethylpiperazine group marketed in the United States and certain other countries.^{[1] [2] [3]} It is used primarily to treat allergy symptoms such as rhinitis, urticaria, and pruritus, and may also be used as an antiemetic.^{[1] [2] [3]} In addition to its antihistamine effects, chlorcyclizine has some anticholinergic, antiserotonergic, and local anesthetic properties.^{[4] [5]} It has been studied as a potential treatment for various flaviviruses like hepatitis C and Zika virus.^{[6] [7] [8]}

See also

• Cyclizine
• Homochlorcyclizine
• Meclizine

Notes and References

1. Book: Swiss Pharmaceutical Society . Index Nominum 2000: International Drug Directory (Book with CD-ROM) . Medpharm Scientific Publishers . Boca Raton . 2000 . 3-88763-075-0 .
2. Book: Triggle DJ . Dictionary of Pharmacological Agents . Chapman & Hall/CRC . Boca Raton . 1996 . 0-412-46630-9 .
3. Book: Hall JA, Morton I . Concise dictionary of pharmacological agents: properties and synonyms . Kluwer Academic . 1999 . 0-7514-0499-3 .
4. Book: Dorland Staff . Dorland Dictionnaire Medical Bilingue Francais-anglais / Anglais-francais: + E-book a Telecharger . Elsevier (Educa Books) . 2008 . 978-2-84299-899-8 . French .
5. Rogóz Z, Skuza G, Sowińska H . The effect of the antihistaminic drugs on the central action of 5-hydroxytryptophan in mice . Polish Journal of Pharmacology and Pharmacy . 33 . 4 . 459–465 . November 1981 . 6120505 .
6. He S, Lin B, Chu V, Hu Z, Hu X, Xiao J, Wang AQ, Schweitzer CJ, Li Q, Imamura M, Hiraga N, Southall N, Ferrer M, Zheng W, Chayama K, Marugan JJ, Liang TJ . 6 . Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection . Science Translational Medicine . 7 . 282 . 282ra49 . April 2015 . 25855495 . 6420960 . 10.1126/scitranslmed.3010286 .
7. Chamoun-Emanuelli AM, Pécheur EI, Chen Z . Benzhydrylpiperazine compounds inhibit cholesterol-dependent cellular entry of hepatitis C virus . Antiviral Research . 109 . 141–148 . September 2014 . 25019406 . 10.1016/j.antiviral.2014.06.014 .
8. Santos FR, Nunes DA, Lima WG, Davyt D, Santos LL, Taranto AG, Ferreira JM . Identification of Zika Virus NS2B-NS3 Protease Inhibitors by Structure-Based Virtual Screening and Drug Repurposing Approaches . Journal of Chemical Information and Modeling . 60 . 2 . 731–737 . February 2020 . 31850756 . 10.1021/acs.jcim.9b00933 . 209409716 .