Chinmoy Sankar Dey Explained

Chinmoy Sankar Dey
Birth Date:18 March 1961
Birth Place:Kolkata, West Bengal, India
Nationality:Indian
Known For:Studies on insulin resistance

Chinmoy Sankar Dey (born 18 March 1961) is an Indian molecular biologist and a professor at Kusuma School of Biological Sciences of the Indian Institute of Technology, Delhi. Known for his research on insulin resistance, Dey's is a J. C. Bose National Fellow of the Department of Science and Technology and an elected fellow of the National Academy of Sciences, India and the Indian National Science Academy. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Medical Sciences in 2003. He is also a recipient of the National Bioscience Award for Career Development of the Department of Biotechnology.

Biography

S. C. Dey was born on 18 March 1961 in Kolkata, the capital of the Indian state of West Bengal.[1] He graduated in zoology from the University of Calcutta in 1982 and continued at the institution to obtain a master's degree in 1984.[2] Afterwards, he joined the Indian Institute of Chemical Biology, in Kolkata, as a research fellow for his doctoral studies and submitted his thesis Biochemical regulation of sperm motility, which earned him a PhD from Jadavpur University in 1990.[3] He did his post-doctoral studies initially at California Institute of Technology from 1988 to 1991 as a post-doc research fellow and later, at the Baylor College of Medicine, as a post-doc research associate from 1991 to 1992. On his return to India in 1992, he started his career by joining the National Institute of Immunology as a pool officer, but his stay there lasted only for two years.

In 1994, he moved to National Institute of Pharmaceutical Education and Research, Mohali as an assistant professor at the department of biotechnology where he served for over a decade and a half. During this period, he held positions as an associate professor (1999–2002) as well as a professor (2002–10), and he became head of the department in 2004. In 2010, he moved his base to New Delhi to join the Indian Institute of Technology at Kusuma School of Biological Sciences as a professor[4] [5] and is the head of the Central Research Facility.[6] He leads a laboratory at IIT Delhi involved in research on Insulin-resistant diabetes and hosts a number of scholars and students.[7] He also serves as a visiting scientist at Madras Diabetes Research Foundation (MDRF).[8]

Legacy

Dey's research has been focusing on the drug resistance of two diseases, leishmaniasis and diabetes. His work on insulin resistance included the development of an in-vitro model, which has potential applications in screening anti-diabetic drugs.[9] [10] The model, which involved insulin-resistant cultured skeletal muscle cells, earned him a US patent.[11] Using the model in tandem with biochemical and gene silencing methodologies, he demonstrated that focal adhesion kinases and p38 mitogen-activated protein kinases could be used as possible drug targets.[12] His team identified for the first time the apoptosis-like cell death in Type II topoisomerase and suggested the enzyme as a possible treatment protocol for Leishmaniasis. His findings were published in a 2005 article in Molecular and Biochemical Parasitology of Elsevier.[13] He also proposed eIF4A, a member of a set of three related proteins, as a drug target to combat infection with Leishmania donovani, a Miltefosine-resistant type of trypanosome causing leishmaniasis. His work on myogenesis and muscular dystrophy showed insulin‑mediated dephosphorylation of PTK2 (focal adhesion kinase) could be stopped by inhibiting the activity of the insulin receptor tyrosine kinase, which was a new discovery. His research has been documented in numerous articles;[14] ResearchGate, an online repository of scientific articles, lists 90 of them.[15] Besides this he has contributed chapters to two books,[16] [17] and his work has drawn citations from other researchers.[18] [19] [20] James Watson, a recipient of the Nobel Prize in Physiology or Medicine in 1962, cited one of Dey's papers in his 2013 lecture at University of California, Los Angeles to commemorate the 60th anniversary of the discovery of double helical structure DNA, which was later published as an article in Lancet in 2014.[21] He also holds a Patent Cooperation Treaty and his aforementioned US patent, as well as two Indian patents, and has guided students in their master's and doctoral studies.

Dey was the Sectional Secretary of the 91st Indian Science Congress held in 2003; he was also associated with the organization of the Indo‑US Symposium on Recombinant DNA Technology and Its Application in Drug Discovery held at BITS, Pilani in February 1999 and the workshops on Molecular Basis of Drug Discovery and on Molecular Modeling and Pharmainformatics held at National Institute of Pharmaceutical Education and Research, Mohali in 2005. He was the regional associate editor of the Journal of Biopharmaceutics and Biotechnology in 2006 and is a former member of the editorial boards of the now defunct Open Parasitology Journal of Bentham Science Publishers and Scientific Reports of Nature Publishing Group. He is a reviewer for Molecular Biology International, a journal of the Hindawi Publishing Corporation,[22] the Diabetes journal of the American Diabetes Association, The FASEB Journal, the Molecular Medicine journal, FEBS Letters, the Journal of Molecular Cell Biology, Antimicrobial Agents and Chemotherapy, the British Journal of Pharmacology, Comparative Biochemistry and Physiology, Expert Opinion on Biological Therapy, the Indian Journal of Medical Research, and Experimental Parasitology. He has also served as an adviser or consultant to pharmaceutical companies such as Orchid Chemicals and Pharmaceutical Ltd., TCG Lifesciences (former Chembiotek Research International) and DSM Anti-Infectives.

Awards and honors

The Council of Scientific and Industrial Research awarded him Shanti Swarup Bhatnagar Prize, one of the highest Indian science awards in 2003.[23] The same year, he also received the National Bioscience Award for Career Development of the Department of Biotechnology,[24] followed by the OPPI Award of the Organisation of Pharmaceutical Producers of India in 2005.[25] He became an elected fellow of two major Indian science academies in 2007: the National Academy of Sciences, India[26] and the Indian National Science Academy.[27] He received two honors in 2008: the CDRI Award of the Central Drug Research Institute[28] and the J. C. Bose National Fellowship of the Department of Biotechnology.[29] [30] In 2011, he was awarded the inaugural Honor Lecture Award by Madras Diabetes Research Foundation. He is also a life member of the Society of Biological Chemists, India.

Selected bibliography

Book chapters

Articles

Patents

See also

External links

Further reading

Notes and References

  1. Web site: Faculty Profile A . 2017 . Bioschool, IIT Delhi . 26 March 2017 . https://web.archive.org/web/20170327081309/http://bioschool.iitd.ac.in/csdeycvfeb2017.pdf . 27 March 2017 . dead . dmy-all .
  2. Web site: Faculty Profile B . 2017 . Bioschool, IIT Delhi.
  3. Web site: Indian fellow . 2017 . Indian National Science Academy . 22 April 2017 . 5 February 2020 . https://web.archive.org/web/20200205154104/http://insaindia.res.in/detail/P07-1433 . dead .
  4. Web site: Faculty . 2017 . Bioschool, IIT Delhi.
  5. Web site: Chinmoy Shankar Dey : Biological Sciences . 2017 . IIT Delhi.
  6. Web site: Contact Us . 2017 . Central Research Facility, IIT Delhi.
  7. Web site: Chinmoy S. Dey's Lab . 2017 . Bioschool, IIT Delhi.
  8. Web site: MDRF honours IIT Delhi professor . 22 July 2011 . News 18.
  9. Web site: Brief Profile of the Awardee . 2017 . Shanti Swarup Bhatnagar Prize.
  10. Web site: Handbook of Shanti Swarup Bhatnagar Prize Winners . Council of Scientific and Industrial Research . 71 . 1999 . 26 March 2017 . https://web.archive.org/web/20160304043957/http://www.csirhrdg.res.in/ssb.pdf . 4 March 2016 . dead .
  11. Web site: Skeletal cell model to screen anti-diabetic compounds . Chinmoy Sankar Dey . 30 May 2006 . Justia Patents . US Patent No. 7052910.
  12. Web site: Shanti Swarup Bhatnagar Prize‑winner Prof. Chinmoy Sankar Dey's Work . 2017 . NISCAIR.
  13. Singh G, Jayanarayan KG, Dey CS. Novobiocin induces apoptosis-like cell death in topoisomerase II over-expressing arsenite resistant Leishmania donovani . Mol Biochem Parasitol. . May 2005 . 141 . 1 . 57–69 . 10.1016/j.molbiopara.2005.01.014 . 15811527.
  14. Web site: Scholarly Contributions . 2017 . Hindawi.
  15. Web site: On ResearchGate . 2017 .
  16. Book: Shio Kumar Singh (editor). G. C. Majumdar, S. C. Dey, S. Saha, K. Das, D. Nath. A. Maiti, S. Dey, D. Roy. S. Mitra, A. Rana, J. Chakrabarty, S. Das, A. Bhoumik, S. Banerjee, M. Mandal, B. S. Jaiswal, P. Ghosh, A. Das, D. Bhattacharyya, S. R. Dungdung (chapter authors). Mammalian Endocrinology and Male Reproductive Biology. https://books.google.com/books?id=Y-KYCgAAQBAJ&pg=PA197. 4 September 2015. CRC Press. 978-1-4987-2736-5. 197–. Role of Sperm Surface Molecules in Motility Regulation.
  17. Book: Shio Kumar Singh (editor). S. C. Dey (chapter author). Mammalian Endocrinology and Male Reproductive Biology. 4 September 2015. CRC Press. 978-1-4987-2736-5. 14–.
  18. Book: Vanete Thomaz Soccol. Ashok Pandey. Rodrigo R. Resende. Current Developments in Biotechnology and Bioengineering: Human and Animal Health Applications. 17 September 2016. Elsevier Science. 978-0-444-63671-3. 588–.
  19. Book: Studies in Natural Products Chemistry. 15 March 2013. Newnes. 978-0-444-62609-7. 427–.
  20. Book: Hemanta K. Majumder. Drug Targets in Kinetoplastid Parasites. 15 September 2008. Springer Science & Business Media. 978-0-387-77570-8. 7–.
  21. Type 2 diabetes as a redox disease . Lancet . 2014 . 383 . 9919 . 841–43 . 10.1016/s0140-6736(13)62365-x. 24581668 . Watson . James D. . 1076963 .
  22. Web site: Molecular Biology International . 2017 . Hindawi . dead . https://web.archive.org/web/20170327080703/https://www.hindawi.com/journals/mbi/reviewers/ . 2017-03-27 .
  23. Web site: Medical Sciences . 2017 . Council of Scientific and Industrial Research . dead . https://web.archive.org/web/20130224074105/http://www.csir.res.in/External/Heads/career/award/BPRIZE/Medical_SCIENCES.htm . 2013-02-24 .
  24. Web site: Awardees of National Bioscience Awards for Career Development . 2016 . Department of Biotechnology . 26 March 2017 . 4 March 2018 . https://web.archive.org/web/20180304191331/http://dbtindia.nic.in/wp-content/uploads/2014/03/list_of_bioscience_awardees.pdf . dead .
  25. Web site: OPPI Award . 2017 . NIPER . 26 March 2017 . https://web.archive.org/web/20060624231921/http://www.niper.ac.in/oppi.htm . 24 June 2006 . dead .
  26. Web site: NASI Year Book 2015 . 2017 . National Academy of Sciences, India . dead . https://web.archive.org/web/20150806211716/http://www.nasi.org.in/Year%20Book%202015.pdf . 2015-08-06 .
  27. Web site: INSA Year Book 2016 . 2017 . Indian National Science Academy . 26 March 2017 . https://web.archive.org/web/20161104001952/http://www.insaindia.res.in/pdf/YearBook_2016.pdf . 4 November 2016 . dead .
  28. Web site: CDRI Award . 2017 . Central Drug Research Institute . 26 March 2017 . https://web.archive.org/web/20170327081308/http://www.cdri.res.in/HonoursAwards.aspx . 27 March 2017 . dead .
  29. Web site: J C Bose fellowship . 2017 . NIPER.
  30. Web site: NASI fellows . 2017 . National Academy of Sciences, India . dead . https://web.archive.org/web/20150717020647/http://www.nasi.org.in/fellows.asp?RsFilter=D . 2015-07-17 .

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