| Country: | CHN |
| Type: | G |
| Route: | 581 |
| Terminus A: | Kashgar |
| Terminus B: | Erkeshtam |
| Previous Type: | G |
| Previous Route: | 580 |
| Next Type: | G |
| Next Route: | 601 |
China National Highway 581 runs between Kashgar and Erkeshtam on the border with Kyrgyzstan.[1] It is also known as the Sary-Tash-Ulugqat road and it was part of Asian Highway 65, superseded by the G3013 Artux–Erkeshtam Expressway.