Cherenkov luminescence imaging explained

Cherenkov luminescence imaging (CLI) is an emerging imaging modality,^[1] similar to bioluminescence imaging, that captures visible photons emitted by Cherenkov radiation. It basically is the optical imaging of radiotracers that emit charged particles traveling faster than the phase velocity of light in that particular medium. It can be used to quickly evaluate radio tracers in preclinical research^{[2] [3] [4]} but also to obtain clinical images in patients.^[5] While radioactivity itself can not be modified, the emitted light provides an opportunity to generate radioactivity-based activatable or "smart" imaging agents that sense for example enzymatic activity.^[6]

References

• G. S. . Mitchell . R. K. . Gill . D. L. . Boucher. S. R. . Cherry. Philosophical Transactions of the Royal Society A. 369 . 4605–4619 . 2011 . In vivo Cerenkov luminescence imaging: a new tool for molecular imaging . 1955 . 10.1098/rsta.2011.0271 . 2011RSPTA.369.4605M . 3263789 . 22006909.

External links

• Web site: 2022-04-18 . A new nuclear imaging prototype detects tumors' faint glow . Science News . en-US.

Notes and References

1. Ciarrocchi . Esther . Belcari . Nicola . 2017 . Cerenkov luminescence imaging: physics principles and potential applications in biomedical sciences . EJNMMI Physics . en . 4 . 1 . 14 . 10.1186/s40658-017-0181-8 . 2197-7364 . 5346099 . 28283990 . free .
2. 3068779. 2010. Ruggiero. A. Cerenkov luminescence imaging of medical isotopes. Journal of Nuclear Medicine. 51. 7. 1123–1130. Holland. J. P.. Lewis. J. S.. Grimm. J. 10.2967/jnumed.110.076521. 20554722.
3. 2011. Zhong. J.. Cerenkov luminescence tomography for in vivo radiopharmaceutical imaging. International Journal of Biomedical Imaging. 2011. 641618. Qin. C.. Yang. X.. Zhu. S.. Zhang. X.. Tian. J. 10.1155/2011/641618. 1–6. 3124671. 21747821. free.
4. 2018. Desvaux. E.. Cherenkov luminescence imaging is a fast and relevant preclinical tool to assess tumour hypoxia in vivo. EJNMMI Research. 8. Courteau. A.. Bellaye. PS.. Guillemin. M.. Drouet. C.. Walker. P.. Collin. B.. Decreau. R. A.. 1. 10.1186/s13550-018-0464-7. 1–6. 30574662. 6301908 . free .
5. 3903390. 2013. Thorek. D. L.. Clinical Cerenkov Luminescence Imaging of 18F-FDG. Journal of Nuclear Medicine. 55. 1. 95–98. Riedl. C. C.. Grimm. J. 10.2967/jnumed.113.127266. 24078721.
6. 10.1038/nm.3323. 24013701. Quantitative imaging of disease signatures through radioactive decay signal conversion. Nature Medicine. 19. 10. 1345–50. 2013. Thorek. Daniel L J. Ogirala. Anuja. Beattie. Bradley J. Grimm. Jan. 3795968.