Chenghua Gu Explained

Chenghua Gu is a Professor of Neurobiology at the Harvard Medical School where her research focuses on the Blood–brain barrier.[1] She is also part of the Harvard Brain Science Initiative and has won numerous awards for her groundbreaking research on the brain's vascular component.

Education

Gu earned her Ph.D. at Cornell Medical School. She then joined the lab of David Ginty at the Johns Hopkins University School of Medicine where she studied the role of semaphorin signaling in vascular development.[2] [3]

Research

Gu's research focuses on the development of the blood-brain barrier and its interaction with neuronal networks.[4] [5] She uses experimental techniques such as Two-photon excitation microscopy, mouse genetics and computational models to study neurovascular coupling, the regulation of blood flow by changes in neuronal activity, and vascular patterning.[6] Her laboratory has recently published on the importance of the inhibition of transcytosis for maintaining blood-brain barrier integrity and how the mechanisms regulating transcytosis levels could be manipulated to aid the entry of therapeutics into the central nervous system.[7] [8]

Award and honors

External links

Notes and References

  1. Web site: Chenghua Gu Department of Neurobiology. neuro.hms.harvard.edu. 2019-12-07.
  2. Gu. Chenghua. Yoshida. Yutaka. Livet. Jean. Reimert. Dorothy V.. Mann. Fanny. Merte. Janna. Henderson. Christopher E.. Jessell. Thomas M.. Kolodkin. Alex L.. Ginty. David D.. 2005-01-14. Semaphorin 3E and Plexin-D1 Control Vascular Pattern Independently of Neuropilins. Science. en. 307. 5707. 265–268. 10.1126/science.1105416. 0036-8075. 15550623. 2005Sci...307..265G. 36470855 . free.
  3. Gu. Chenghua. Rodriguez. E. Rene. Reimert. Dorothy V.. Shu. Tianzhi. Fritzsch. Bernd. Richards. Linda J.. Kolodkin. Alex L.. Ginty. David D.. July 2003. Neuropilin-1 Conveys Semaphorin and VEGF Signaling during Neural and Cardiovascular Development. Developmental Cell. 5. 1. 45–57. 1534-5807. 3918747. 12852851. 10.1016/s1534-5807(03)00169-2.
  4. Ben-Zvi. Ayal. Lacoste. Baptiste. Kur. Esther. Andreone. Benjamin J.. Mayshar. Yoav. Yan. Han. Gu. Chenghua. 2014-05-22. MSFD2A is critical for the formation and function of the blood brain barrier. Nature. 509. 7501. 507–511. 10.1038/nature13324. 0028-0836. 4134871. 24828040. 2014Natur.509..507B.
  5. Lacoste. Baptiste. Comin. Cesar H.. Ben-Zvi. Ayal. Kaeser. Pascal S.. Xu. Xiaoyin. Costa. Luciano da F.. Gu. Chenghua. 2014-09-03. Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex. Neuron. 83. 5. 1117–1130. 10.1016/j.neuron.2014.07.034. 0896-6273. 4166422. 25155955.
  6. Lacoste. Baptiste. Gu. Chenghua. November 2015. Control of cerebrovascular patterning by neural activity during postnatal development. Mechanisms of Development. 138 Pt 1. 43–49. 10.1016/j.mod.2015.06.003. 0925-4773. 4663105. 26116138.
  7. Andreone. Benjamin J.. Chow. Brian Wai. Tata. Aleksandra. Lacoste. Baptiste. Ben-Zvi. Ayal. Bullock. Kevin. Deik. Amy A.. Ginty. David D.. Clish. Clary B.. Gu. Chenghua. 2017-05-03. Blood-brain barrier permeability is regulated by lipid transport-dependent suppression of caveolae-mediated transcytosis. Neuron. 94. 3. 581–594.e5. 10.1016/j.neuron.2017.03.043. 0896-6273. 5474951. 28416077.
  8. Chow. Brian Wai. Gu. Chenghua. 2017-03-22. Gradual suppression of transcytosis governs functional blood-retinal barrier formation. Neuron. 93. 6. 1325–1333.e3. 10.1016/j.neuron.2017.02.043. 0896-6273. 5480403. 28334606.
  9. Web site: Three Harvard Medical School scientists receive prestigious Allen awards. EurekAlert!. en. 2019-12-07.
  10. Web site: Faculty Scholars Program. HHMI.org. en. 2019-12-07.
  11. Web site: NIH Director's Pioneer Award Program - 2014 Award Recipients NIH Common Fund. commonfund.nih.gov. 2019-12-07.
  12. Web site: Brain vasculature at the neuro-immune interface. alleninstitute.org. 2019-12-07.
  13. Web site: The Esther A. & and Joseph Klingenstein Fund, Inc.. www.klingfund.org. 2019-12-07.

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