| retinoic acid receptor responder (tazarotene induced) 2 | |
| Hgncid: | 9868 |
| Symbol: | RARRES2 |
| Altsymbols: | chemerin |
| Entrezgene: | 5919 |
| Omim: | 601973 |
| Refseq: | NM_002889 |
| Uniprot: | Q99969 |
| Chromosome: | 7 |
| Arm: | q |
| Band: | 36.1 |
Chemerin peptides are short peptides (on the order of 9 amino acids) that are produced from the carboxyl terminus of the chemokine chemerin. They display the same activities as chemerin, although at higher efficacy and potency.[1]
A particular synthetic chemerin-derived peptide, termed C15, was developed at Oxford University. It showed anti-inflammatory activities. Intraperitoneal administration of C15 (0.32 ng/kg) to mice before zymosan challenge conferred significant protection against zymosan-induced peritonitis, suppressing neutrophil (63%) and monocyte (62%) recruitment with a concomitant reduction in proinflammatory mediator expression.[2]
C15 was found to promote phagocytosis and efferocytosis in peritoneal macrophages at picomolar concentrations. C15 enhanced macrophage clearance of microbial particles and apoptotic cells by factor of 360% in vitro [3]