Che Chi-ming explained

Che Chi-ming
Birth Date:7 September 1957
Birth Place:British Hong Kong
Nationality:Chinese
Occupation:Professor
Researcher
Member of Chinese Academy of Science
Known For:Inorganic Chemistry
Medicinal Chemistry
Notable Works:Metal Catalyst
OLED
Anticancer metal complexes
Doctoral Students:Vivian Yam[1]

Che Chi-ming (; born 7 September 1957), is a Hong Kong chemist currently holding Zhou Guangzhao Professorship in Natural Sciences, following a Dr. Hui Wai-Haan's Chair of Chemistry at The University of Hong Kong (HKU). In 1995, he became the first scientist from Hong Kong to be elected as a member of the Chinese Academy of Sciences.[2] As of today, he remains the youngest academician of the CAS ever to be elected. He is known for extensive work in inorganic chemistry, photochemistry, and medicinal chemistry.[3]

Career

Che received his B.S. degree at HKU in 1978.[4] He then received his Ph. D degree in inorganic chemistry at HKU working under Professor Chung-Kwong Poon in 1980. After earning his Ph. D., he spent 3 years at the California Institute of Technology conducting research in organometallic and bioinorganic chemistry in the laboratory of Harry B. Gray.[5]

Following his research stay in the United States, Che moved back to Hong Kong and started his independent career as a faculty at HKU. During the past 20 years, he has also held visiting lecturer positions at National Taiwan University, Jilin University, and Sun Yat-sen University. Moreover, he has been a professor at Nanjing University, Nankai University, and Tsinghua University; and an honorary professor at Huazhong University of Science and Technology, Northeast Normal University, Nanjing University, and other universities.

In 2007, he was elected as a member of The World Academy of Sciences (TWAS) in Chemical Sciences. In 2013, he was elected as a foreign associate of the United States National Academy of Sciences.

Currently, he is the Zhou Guangzhao Professorship in Natural Sciences and Chair of Chemistry, Department of Chemistry, Faculty of Science, The University of Hong Kong.[2]

In December 2021, it was reported that Che was eligible to vote four times in the 2021 Hong Kong legislative election, yielding 0.0459334% of the total voting value (elected seats), which is 9242 times more than the value of an average voter's total voting value.[6]

Research

Che's research interests cover various areas in chemistry such as inorganic chemistry, materials science, photochemistry, and biomedical sciences.[7] He has been engaged in inorganic chemistry research, organometallic synthesis where he and his group have studied high-valent and multimetallic complexes.[8] These molecules have been investigated for their luminescent and catalytic properties. Notable systems that Che has developed include: catalysts for asymmetric olefin epoxidation,[9] biomimetic oxidation catalyst featuring recognition elements, and molecular devices based on luminescent materials.[10]

Triplet Emitters

Che is a pioneer for the chemistry of d8 and d10 metal complexes including their excited state chemistry and closed shell metal-metal interactions of d8 and d10 metal ions.[11] His team has successfully developed practical tetradentate platinum(II)[12] and gold(III)[13] Emitters which are comparable if not superior in performances to the World best Iridium(III) Phosphors

Metal Catalysts

Che has pioneered the developed of Ru-OXO system which has opened up numerous opportunities for efficient catalytic oxidation processes.[14] [15]

Furthermore, Che and co-workers developed new methods for epoxidation, cyclopropanation, and aziridination of alkenes.[16] His work on bioinorganic chemistry, has produced new understanding for several important processes including modern nitrogen fixation.[17]

Anti-Cancer Metal Complexes

Another notable work from Che's group has been the development of gold-, platinum-, ruthenium- and palladium based metal compounds with anti-tumor activity.[18] [19] [20] Specifically, they found that PEGylated gold(III) conjugates can exhibit multifunctional properties and undergo selective delivery to tumor tissues. Importantly, some of these compounds do not exhibit harmful cytotoxicity to normal cells, as many Pt-based anti-cancer agents do.[21] [22]

Notable awards

Notes and References

  1. Web site: Prof. Vivian Wing-Wah YAM. Vivian YAM Lab. The University of Hong Kong. 17 June 2024.
  2. Web site: Professor CHE, Chi Ming. Teaching Staff. Faculty of Science, The University of Hong Kong. 17 June 2024.
  3. Web site: Chi-Ming Che. www.nasonline.org. 2017-06-05.
  4. Web site: Chi-Ming CHE - Our Members . The Academy of Sciences of Hong Kong. 2017-06-05.
  5. Web site: Prof. Chi-Ming Che - Federation of Asian Chemical Societies. www.facs-as.org. 2017-06-05.
  6. Web site: FactWire. 2021-12-15. Factwire: 41 privileged voters have 7,200 times greater power than a regular Hong Kong voter following election revamp. 2021-12-16. Hong Kong Free Press HKFP. en-GB.
  7. Web site: Professor CHE Chi Ming Croucher Foundation. croucher.org.hk. 19 May 2011 . en-US. 2017-06-05.
  8. Che. Chi Ming.. Cheng. Wing Kin.. 1986-07-01. Novel UV-vis spectral feature and electrochemical behavior of high-valent osmium(VI) dioxo complex of 1,4,8,11-tetramethyl-1,4,8,11-tetraazacyclotetradecane (TMC). Reversible three-electron redox couple and vibronic structured UV-vis absorption bands involving trans-[Os(VI)(TMC)O2]2+. Journal of the American Chemical Society. 108. 15. 4644–4645. 10.1021/ja00275a062. 0002-7863.
  9. Chan. Wing-Kei. Liu. Peng. Yu. Wing-Yiu. Wong. Man-Kin. Che. Chi-Ming. 2004-05-01. Highly Diastereoselective Epoxidation of Allyl-Substituted Cycloalkenes Catalyzed by Metalloporphyrins. Organic Letters. 6. 10. 1597–1599. 10.1021/ol0496475. 15128245. 1523-7060.
  10. Cheng. Gang. So. Gary Kwok-Ming. To. Wai-Pong. Chen. Yong. Kwok. Chi-Chung. Ma. Chensheng. Guan. Xiangguo. Chang. Xiaoyong. Kwok. Wai-Ming. 2015-07-14. Luminescent zinc(II) and copper(I) complexes for high-performance solution-processed monochromic and white organic light-emitting devices. Chemical Science. en. 6. 8. 4623–4635. 10.1039/C4SC03161J. 29142704. 2041-6539. 5667404.
  11. Web site: Chi-Ming CHE - Our Members - the Hong Kong Academy of Sciences 香港科學院.
  12. Cheng . Gang . Kwak . Yoonhyun . To . Wai-Pong . Lam . Tsz-Lung . Tong . Glenna So Ming . Sit . Man-Ki . Gong . Shaolong . Choi . Byoungki . Choi . Wha il . Yang . Chuluo . Che . Chi-Ming . High-Efficiency Solution-Processed Organic Light-Emitting Diodes with Tetradentate Platinum(II) Emitters . ACS Applied Materials & Interfaces . 13 November 2019 . 11 . 48 . 45161–45170 . 10.1021/acsami.9b11715. 31718137 . 207962058 .
  13. Zhou . Dongling . To . Wai-Pong . Tong . Glenna So Ming . Cheng . Gang . Du . Lili . Phillips . David Lee . Che . Chi-Ming . Luminescent Tetradentate Gold(III)-TADF Emitters: Microwave-Assisted Synthesis and High Performance OLEDs With EQEs Up To 25 % and Long Operational Lifetime . Angewandte Chemie . 15 January 2020 . 10.1002/ange.201914661. 243070975 .
  14. Che. Chi Ming. Yam. Vivian Wing Wah. 1987-02-01. Model complexes for the cis-ruthenium(VI)-dioxo system. Novel chemistry of [RuIII(N4O)(OH2)][ClO4]2 (N4OH = bis[2-(2-pyridyl)ethyl][2-hydroxy-2-(2-pyridyl)ethyl]amine). Journal of the American Chemical Society. 109. 4. 1262–1263. 10.1021/ja00238a055. 0002-7863.
  15. Che. Chi-Ming. Ho. Clare. Lau. Tai-Chu. 1991-01-01. Tuning the reactivities of ruthenium–oxo complexes with robust ligands. A ruthenium(IV)–oxo complex of 6,6′-dichloro-2,2′-bipyridine as an active oxidant for stoichiometric and catalytic organic oxidation. J. Chem. Soc., Dalton Trans.. en. 8. 1901–1907. 10.1039/dt9910001901. 1364-5447.
  16. Zhang. Jun-Long. Che. Chi-Ming. 2002-05-01. Soluble Polymer-Supported Ruthenium Porphyrin Catalysts for Epoxidation, Cyclopropanation, and Aziridination of Alkenes. Organic Letters. 4. 11. 1911–1914. 10.1021/ol0259138. 12027645. 1523-7060.
  17. Che. Chi-Ming. Lam. Hon-Wah. Tong. Wai-Fong. Lai. Ting-Fong. Lau. Tai-Chu. 1989-01-01. Model reactions for nitrogen fixation. Photo-induced formation and X-ray crystal structure of [Os2(NH3)8(MeCN)2(N2)]5+ from [OsVI(NH3)4N]3+]. Journal of the Chemical Society, Chemical Communications. en. 24. 1883–1884. 10.1039/C39890001883. 0022-4936.
  18. Zou . Taotao . Lum . Ching Tung . Lok . Chun-Nam . Zhang . Jing-Jing . Che . Chi-Ming . Chemical biology of anticancer gold and gold complexes . Chemical Society Reviews . 2015 . 44 . 24 . 8786–8801 . 10.1039/C5CS00132C. 25868756 .
  19. Zou . Taotao . Lok . Chun-Nam . Wan . Pui-Ki . Zhang . Zhi-Feng . Fung . Sin-Ki . Che . Chi-Ming . Anticancer metal-N-heterocyclic carbene complexes of gold, platinum and palladium . Current Opinion in Chemical Biology . April 2018 . 43 . 30–36 . 10.1016/j.cbpa.2017.10.014. 29136524 .
  20. Che . Chi-Ming . Siu . Fung-Ming . Metal complexes in medicine with a focus on enzyme inhibition . Current Opinion in Chemical Biology . April 2010 . 14 . 2 . 255–261 . 10.1016/j.cbpa.2009.11.015. 20018553 .
  21. Web site: A multi-functional PEGylated gold(iii) compound: potent anti-cancer properties and self-assembly into nanostructures for drug co-delivery. ResearchGate. en. 2017-06-05.
  22. Lum. Ching Tung. Liu. Xiong. Sun. Raymond Wai-Yin. Li. Xiang-Ping. Peng. Ying. He. Ming-Liang. Kung. Hsiang Fu. Che. Chi-Ming. Lin. Marie C. M.. 2010-08-28. Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro. Cancer Letters. 294. 2. 159–166. 10.1016/j.canlet.2010.01.033. 1872-7980. 20163914.

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